Abstract:
Aim: To determine the intensity of posttraumatic oxidative stress (OS) in patients with mild explosive traumatic brain injury (METBI) complicated by acoustic
barotrauma and its association with sensorineural hearing loss (SHL) occurrence.
Materials and Methods: This study included 43 patients with METBI form October 2023 to May 2024.
Results: METBI initiated an increase in OS markers in blood: aldehyde phenylhydrazone (APH) by 53.54% (p<0.05), carboxy phenylhydrazone (CPH) - by
50.51% (p<0.05) and with a deficiency of the antioxidant system of reduced glutathione by 47.4% (p<0.05), total thiols by 61.7% (p<0.05), decrease in the
level of nitric oxide in blood by 54.22% (p<0.05), which led to microcirculatory disorder. A direct correlation was established between the frequency of SHL
and an increase of APH (r=+0.72, p<0.05), CPH (r=+0.66, p<0.05) and an inverse correlation with a reduced glutathione deficiency (r=-0.85, p<0.05).
Conclusions: An imbalance of antioxidant protection led to significant microcirculatory disorders. The data obtained are important for the neutralization of
the effect of damaging factors of OS on thе inner ear microcirculation.
