Correlation analysis of GSTP1 gene polymorphism with morbidity of metastatic ovarian cancer

Abstract

Ovarian canceris one of the most common gynecological malignancies. Susceptibility to malignant processes is mediated by genetically driven differences in the effectiveness of detoxification of potential carcinogens. One of the factors that may inf luence the risk of ovarian cancer is the glutathione-S-transferase (GST) gene family that encodes glutathione transferase enzymes. The GSTP1 gene is expressed both in normal and pathological conditions. Determining its specific alleles may be a marker of ovarian cancer. Thisimprovement, at least in part, may be related to more effective primary and adjuvant treatments, and the improvement of instrumental and laboratory diagnostic methods, in particular molecular studies. The aim of the research–to study GSTP1 gene polymorphism, which is likely to be more common among patients with metastatic ovarian cancer compared with healthy population.