Histomorphological characteristics of orbital carcinoma in the context of stem cell therapy

Abstract

Introduction. In the last two decades, the use of stem cells in clinical medicine has found wide application. Thus, in addition to the longestablished positive effect of hematopoietic stem cell transplantation in the treatment of leukemia and other systemic blood diseases, the use of stem cells for the correction of neurodegenerative diseases is becoming widespread. At the same time, concerns are expressed related to theoretical assumptions about the possible immunosuppressive effect of stem cells on the immune system, which increases the risk of developing cancer. Although there is no proven evidence that the immunosuppressive effects of stem cells are more dangerous than those of immunosuppressive therapy using drugs, this does not alleviate the fears sometimes further fueled in society by the media. In any case, the question of the possibility of oncogenic transformation of stem cells remains open, especially given that both cell types exhibit histomorphological and immunohistochemical patterns of embryonic cells. Aim. To present the histomorphological and immunohistochemical characteristics of a unique observation of an orbital neoplasm that developed after stem cell injection.