Abstract:
This publication initiates the project "Neuro-endocrine regulation of the
clearance of nitrogenous metabolites". The first stage of project implementation is the
clarification of peculiarities of metabolic and neuro-endocrine accompaniments of uratelosing and urate-retaining kidneys. Materials and Methods. The object of observations were
patients with chronic pyelonephritis in the phase of remission (34 males aged 23-70 years and
10 females aged 33-76 years). Testing was performed twice - on admission and after 7-10
days of standard balneotherapy on Truskavets Spa. The battery of tests was created in line
with concepts functional-metabolic continuum and NEI network. The content of nitrogenous
metabolites and electrolytes was determined in daily urine and blood serum. In addition,
indicators of the lipoprotein spectrum and lipids peroxidation, as well as the level of the main
adaptation hormones, were determined in the blood. The state of the autonomic nervous
system was assessed by the HRV method. Results. In 63.6% of cases, the renal clearance of
uric acid was within the classical norm (±2σ), in 12.5% it was moderately reduced, but in the
remaining cases it was increased, including drastically in 3 cases. The method of discriminant
analysis revealed 20 parameters, according to the totality of which all 4 clusters of uric acid
clearance clearly differ from each other (classification accuracy 100%). Conclusion.
Constitutionally distinct types of uric acid metabolism (euricosis, urate-losing and urateretaining kidneys) are characterized by specific constellations of metabolic and autonomicendocrine parameters.
