New model of pharmacoresistance epilepsy

Abstract

Interest in epilepsy is caused by both the widespread occurrence of this pathology and the severity of its course. The most common treatment option is pharmacotherapy with antiepileptic drugs (AEDS). The efficiency of using AEDs depends on the activity of metabolic and biotransformation processes. The cytochrome P450 system is an important enzymatic system participating in the biotransformation of medicinal substances, including antiepileptic drugs. The activity of the cytochrome P450 system depends on the characteristics of the combinations of individual enzyme isoforms that represent it and are determined by the human genotype. Aim. The presented work was aimed at studying the polymorphism of the genes of the cytochrome P450 system in patients suffering from drug-resistant forms of epilepsy. In addition, the features of the anticonvulsant action of some antiepileptic drugs were studied on an experimental model of drug-resistant epilepsy.