On different mechanisms of axitinib and diazepam antiseizure action in pentylenetetrazol-induced kindling model

Abstract

PTZ-induced kindling exhibits resistance to antiepileptic medication, increased brain-blood barrier. Tyrosine kinase inhibitors demonstrated antiepileptic efficacy, suggesting that VEGF-induced angiogenesis plays a part in the development of persistent epileptic activity. This study used PTZ-kindled rats to assess the histomorphology features of the hippocampus structures and ascertain the degree of seizures following treatment with axitinib and diazepam, tyrosine kinase B inhibitors, throughout fully developed and postponed phases.