Silent abortion and Vaginal Microbiome – Therapy Pathway

Abstract

The problem of spontaneous pregnancy termination or miscarriage occupies one of the leading places in obstetric practice. According to statistics, miscarriages occur in 15% of clinically confirmed pregnancies in the general population. New evidence indicates that the reproductive tract microbiome plays an important role in immune responses, both local and general, in the pregnant woman body. During pregnancy, the increased estrogen level contributes to glycogen accumulation in the vaginal epithelium, which, accordingly, supports Lactobacillus spp. dominance and stability during pregnancy. Today, although we have a number of recent data that indicate the role of the vaginal and cervical canal microbiome as a predictor of miscarriage.