Rapamycin combined with pitolisant alleviates anxiety and depression in pentylenetetrazol (PTZ) kindled rats

dc.contributor.author	Pervak, M. P.	en
dc.contributor.author	Poshyvak, O. B.	en
dc.contributor.author	Yehorenko, O. S.	en
dc.contributor.author	Arabadzhy, D. R.	en
dc.contributor.author	Marchenko, S. V.	en
dc.date.accessioned	2025-01-21T15:04:47Z
dc.date.available	2025-01-21T15:04:47Z
dc.date.issued	2024
dc.identifier.citation	Rapamycin combined with pitolisant alleviates anxiety and depression in pentylenetetrazol (PTZ) kindled rats / M.P. Pervak et al. Acta Neurobiologiae Experemintale. 2024. Vol. 8, Suppl. I–CLXVIII . P. 162. (Poster Session III CLIX)	en
dc.identifier.uri	https://repo.odmu.edu.ua:443/xmlui/handle/123456789/16670
dc.description.abstract	The work aimed to investigate the anxiety and depression manifestations in PTZ‐kindled rats under combined treatment with the rapamycin and histamine H3 receptor inverse agonist pitolisant. Kindling was produced in Wistar male rats by administration of three‐week PTZ (35.0 mg/kg, i.p.). Treatment with rapamycin (Pfizer, 0.5 mg/kg) and pitolisant (Selleck, 5.0 mg/kg) was performed for ten days in fully kindled rats. Control rats were treated with DMSO. Kindled an‐ imals spent less time (2.7 times) in the open area of the elevated plus maze (EPM) in comparison to the control (P<0.001). F	en
dc.language.iso	en	en
dc.subject	depression manifestations	en
dc.subject	PTZ‐kindled rats	en
dc.subject	rapamycin	en
dc.title	Rapamycin combined with pitolisant alleviates anxiety and depression in pentylenetetrazol (PTZ) kindled rats	en
dc.type	Article	en