On metabolic deteriorations in pentylenetetrazol (PTZ) kindled rats revealed with glucose tolerance test and liver histology

Abstract

Manifestations of metabolic syndrome (MS) man‑ ifestations in chronic epilepsy models were in the scope of the investigation. Kindling was induced by daily injections of PTZ at a dose of 35 mg/kg i.p. for three weeks. Those animals with fully developed gen‑ eralized seizures were used for investigations. Glucose and insulin levels were not different from control rats, while PTZ‑kindled rats demonstrated decreased tol‑ erance to glucose tests.