Daytime sleep-wakefulness cycle disturbances are effectively reversed with pitolisant in pentylenetetrazol-kindled rats

dc.contributor.author	Yehorenko, O. S.	en
dc.contributor.author	Pervak, M.	en
dc.contributor.author	Latypov, K. A.	en
dc.contributor.author	Prybolovets, K.	en
dc.contributor.author	Shcheglov, I. A.	en
dc.contributor.author	Godlevsky, L. S.	en
dc.date.accessioned	2024-06-18T11:16:31Z
dc.date.available	2024-06-18T11:16:31Z
dc.date.issued	2023
dc.identifier.citation	Daytime sleep-wakefulness cycle disturbances are effectively reversed with pitolisant in pentylenetetrazol-kindled rats / O. S. Yehorenko et al. Journal of the Neurological Sciences. 2023. Vol. 455. Abstract No 121569. P. 170–171.	en
dc.identifier.uri	https://repo.odmu.edu.ua:443/xmlui/handle/123456789/15532
dc.description.abstract	Chronic brain eptisation induces sleep-wakefulness (SW) disturbances. The work aimed to investigate SW cycle in pentylenetetrazole (PTZ)- kindled rats under combined treatment with the histamine H₃ inverse agonist pitolisant, which is effective in narcolepsy. Methods: Kindling was produced in 18 Wistar male rats by administration of three-week PTZ (Sigma Aldrich, 35.0 mg/kg, i.p.). Pitolisant (Selleck, 5.0 mg/kg, i.p.) was administered for ten days. SW data were collected over four hours starting from 8.00 AM via behavior, EEG, and EMG registration.	en
dc.language.iso	en	en
dc.subject	chronic brain eptisation	en
dc.subject	sleep-wakefulness cycle	en
dc.title	Daytime sleep-wakefulness cycle disturbances are effectively reversed with pitolisant in pentylenetetrazol-kindled rats	en
dc.type	Article	en