Abstract:
Chronic brain eptisation induces sleep-wakefulness (SW) disturbances.
The work aimed to investigate SW cycle in pentylenetetrazole (PTZ)-
kindled rats under combined treatment with the histamine H₃ inverse
agonist pitolisant, which is effective in narcolepsy.
Methods: Kindling was produced in 18 Wistar male rats by administration of
three-week PTZ (Sigma Aldrich, 35.0 mg/kg, i.p.). Pitolisant (Selleck,
5.0 mg/kg, i.p.) was administered for ten days. SW data were collected
over four hours starting from 8.00 AM via behavior, EEG, and EMG
registration.
