The use of immunological drugs for the treatment of wound infections in military personnel during hostilities

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dc.contributor.author Gai, L. en
dc.contributor.author Hruzevskyi, O. en
dc.contributor.author Koltsova, I. en
dc.contributor.author Dubina, A. en
dc.contributor.author Tabulina, A. en
dc.date.accessioned 2024-06-17T11:35:09Z
dc.date.available 2024-06-17T11:35:09Z
dc.date.issued 2024
dc.identifier.citation The use of immunological drugs for the treatment of wound infections in military personnel during hostilities / L. Gai, O. Hruzevskyi, I. Koltsova et al. // Future Med. 2024. No. 3 (1). P. 59–70. en
dc.identifier.uri https://repo.odmu.edu.ua:443/xmlui/handle/123456789/15523
dc.description.abstract Aims: To assesses the trends in immunological drug development for managing wound infections in military personnel. To discuss the efficacy, safety, and long-term results, focusing on combination therapies, and identifying research deficits for improving the care of military wounds. Methodology: A narrative review was used in order to explores the use of immunological drugs for treating wound infections in military settings utilising a search strategy identified 840 publications from PubMed, with 6 studies meeting inclusion criteria for analysis from the years 2019 to 2022. Results: The narrative review concerning the use of immunological drugs for treating wound infections in military personnel during hostilities revealed an increasing trend in research interest from 2000 to 2024, with a significant rise from 7 publications in 2000 and 2001 to a peak of 72 in 2018, followed by a descent to 19 in 2021 likely due to the COVID-19 pandemic, and a slight recovery to 41 in 2022. The key findings included a 50% reduction in infection rates and a 30% faster healing time with monoclonal antibody treatments, over 95% accuracy in species identification of MDR strains, and reduced bacteremia incidence with GM-CSF and G-CSF. Adverse effects varied from mild to moderate, including infusion reactions, nausea, and fatigue. The highlighted challenges included the need for larger sample sizes, long-term follow-up, optimal dosages, and studying diverse populations. Scientific Novelty: Explore the innovative realm of immunological drugs, a promising frontier in combating wound infections among military personnel during active hostilities. Conclusion: The review also identified new developments in immunomodulatory agents for military wound infection, which are effective in decreasing infection rates and enhancing the rate of wound healing. en
dc.language.iso en en
dc.subject wound infections en
dc.subject military personnel en
dc.subject hostilities en
dc.subject immunological drugs en
dc.subject treatment en
dc.title The use of immunological drugs for the treatment of wound infections in military personnel during hostilities en
dc.type Article en


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