Chronopharmacological studies of the hepatoprotective activity of silymarin under experimental toxic hepatitis in rats

Abstract

Silymarin – a complex preparation of bioflavonoids of milk thistle, which contains silibinin A, silibinin B, silocristine, silidianin, isosilibinin A, isosilibinin B, isosilicristin, taxifolin. Chronopharmacological studies of carsil activity will establish a chronoportrait of this drug, which will help increase the effectiveness of pharmacotherapy of diseases of the hepatobiliary system. It was found that against the background of modeling hepatitis in the morning (9 a.m.) and evening (9 p.m.) silymarin was characterized by the most pronounced increase in the level of reduced glutathione and superoxide dismutase activity (group at 9 p.m.). It was investigated that the use of silymarin in the morning (9 a.m.) and in the evening (9 p.m.) was characterized by the most significant positive dynamics of reduction of transminase activity (1.2-1.5 times (p <0.05), in the absence of significant changes at night and only the t rend to their reduction on the background of daytime pathology (alanine aminotransferase by 16%). It is established that the effect of silymarin on energy and metabolic processes by increasing glycogen content by 1.2 times and decreasing uric acid content by 1.2 times is also observed in the morning (9 a.m.) and night (3 a.m.) period. Summarizing the results of the above chronopharmacological preclinical analysis of hepatoprotective properties of silymarin in the model of acute hepatitis modeled at different times of the day, the most pronounced pharmacological effect of the drug when taken in the morning (9 o’clock) and evening (9 o’clock).