Ώ-3 polyunsaturated fatty acids and magnetotherapy combined impact on free radical processes in patients with stable exertional angina

Abstract

Aim: To research the comparative effectiveness of a protocol-based drug complex for angina pectoris and combination therapy using ω-3 polyunsaturated fatty acids and magnetotherapy on the lipid peroxidation and antioxidant system activity dynamics. Materials and Methods: The clinical examination included 97 patients who were randomized into three group of observation depending the variants of treatment. 50 practically healthy persons were involved into the control group. Lipid peroxidation endproducts and antioxidant enzymes activities were determined in blood of the examined patients. Results: Our results revealed the expressed efficacy of the original method of patients with stable exertional angina pectoris physiotherapeutic treatment. The scheme, which we prove to be effective for patients with stable exertional angina pectoris includes, combined used of ω-3 PUFAs and magnetotherapy. Our data allowed to indicate that the therapeutic benefits of our original physiotherapy complex developed faster and were expressed in more effective lipid peroxidation prevention and inhibition of the blood antioxidant system activity compared to those parameters in case of other used therapeutic complexes. Conclusions: We determined an antioxidant efficacy of ω-3 PUFAs and magnetotherapy combined use patients with stable exertional angina pectoris. Continuing a series of similar courses of physiotherapy treatment in these patients with the expressed antioxidant effect, we are confident in its effectiveness, safety, and the absence of side effects, which justifies the expediency of its widespread use in physiotherapy clinics.