Abstract:
60 patients with the resistant arterial hypertension of the 2" degree at the age
of 45 to 74 years were examined. Depending on the undergone treatment all the patients were
divided into two groups. The patients of the control group got Amlodipine, Lisinopril,
Hydrochlorothiazide in maximum tolerable doses, the patients of the main group took the
average therapeutic doses of these preparations and Urapidil in addition. The dynamics of the
complaints, the indices of the office ABP, ECG, laboratorial analyses (ALT, AST, creatinine,
uric acid) were estimated in all patients. More expressed positive dynamics of the subjective
indices, i.e. the shortening of the complaints about precordialgiae, exertional dyspneae in
number, was observed in the patients from the main group. But in the control group the number
of the complaints about headaches grew, the ones about cough, nausea appeared. Only in the
main group the average ABP almost achieved its goal and made 143.8/89.6 mm Hg. In the
whole, the achievement of the goal ABP was noticed in the main group in 21 patients and in 8
ones from the conirol group. The improvement in the processes of repolarization was observed
in the patients from the main group more often than in the patients from the control one: the
growth of the T wave amplitude occurred, reduction in the frequency of the revelation of
isoelectric T wave happened.The combined therapy with the application of Urapidil has allowed the achievement of the
goal ABP at the fewer side effects in the most of the patients.
