Immune mechanisms of implementation of allergic rhinitis and the ways of it correction

Abstract

Allergic rhinitis is a global health problem worldwide. The basis of the pathogenesis of the allergic form of the disease is a type I hypersensitivity reaction. It has been established that in AD (allergic disease) there is a restructuring of the immune system to a Th2 response, which leads to excessive activation of B-lymphocytes, an increase in the synthesis and secretion of IL-4 and IL-5, the development of IgE-dependent reactions, as well as a decrease in the production of IL-2. Despite certain successes achieved in the field of pathophysiology of AR (allergic rhinitis), a number of questions remain regarding the importance of immune mechanisms in the realization of different phenotypes of AR.