Abstract:
Epilepsy is a prolonged, progressively advancing nervous and psychiatric disorder of
various etiologies, characterized by paroxysmal and relatively persistent psychological
disturbances. A significant burden of comorbid pathology is attributed to psychiatric disorders.
Depressive disorders are among the most common behavioral comorbidities in patients with
epilepsy, often remaining undiagnosed and untreated. The approach to treating depression in
epilepsy patients is currently underdeveloped. To fully understand the prospects of the
experimental framework for minimizing and/or eliminating depressive behavioral
manifestations during the interictal period under conditions of chronic epileptogenesis, we
conducted a series of studies to determine the effectiveness of comprehensive correction of nonseizure behavior in kindling animals. The aim of this study is to delineate alterations in the
expression of non-seizure behavior in rats due to the combined administration of Vortioxetine
with antiepileptic drugs in the dynamic context of chronic kindling-induced seizure activity. It
has been established that in rats during the development of Picrotoxin-induced chronic epileptic syndrome, disruptions in late-tonic, emotional, and swimming types of behavior are observed,
which are manifestations of non-seizure behavior. It has been proven that the combined
administration of Valproic acid and Vortioxetine results in successful correction of the tested
forms of behavior. Less effectiveness is observed with vortioxetine alone, and the least
effectiveness is noted in a smaller number of investigated behavior types after valproic acid
administration. The data demonstrate balancing systemic-antisynergistic relationships, the
imbalance of which during the development of picrotoxin-induced chronic epileptic syndrome
allows the development of non-seizure behavior forms during interictal periods. The obtained
data and their analysis provide experimental groundwork for the appropriateness of clinically
testing the combined administration of Vortioxetine with Valproic acid as part of complex
therapy in epilepsy patients with the presence of a depressive behavioral component.
