Abstract:
The purpose: to justify a differentiated approach to the management of patients with
hyperplastic uterine diseases complicated by abnormal uterine bleeding (AUB) based on the
study of the morpho-functional features of the endo- and myometrium. It has been shown that
PgR expression is low in patients with combined lesions of the endometrium and
myometrium complicated by AMC. The degree of PgR expression has a strong negative
correlation with pathological changes of the endometrial-myometrial junction (r=-0.71),
which made it possible to consider these criteria in the creation of a differentiated algorithm
for the management of patients taking into account clinical and morphological pathogenetic
variants of the disease. The use of differentiated approaches to the treatment of patients with
combined hyperplastic processes of the uterus, taking into account the clinical and
morphological features of the disease, made it possible to reduce the number of recurrences of
AMC and achieve a long-term clinical effect in comparison with traditional treatment.
