Вплив лактопротеїну з сорбітолом та HAEX-LX 5% на зміни гормональної активності щитоподібної залози при її термічному ураженні

Abstract

The urgency of the body thermal damage is generally recognized in medicine. The severity of burn injury clinical manifestation, their polymorphism and versatility, the duration, complexity and high cost of treatment are known already. Burn damage of the organism and the thyroid gland initiates serious pathomorphological consequences which manifestation results in the thyroid gland and surrounding tissues predominant destruction and the decompensatory changes formation throughout 14 days of the post-burn period. We focused our attempts at the thyroid gland burn lesions pharmacological correction. The aim of the work is to study the effect of lactoprotein with sorbitol and HAES-LX-5% on the expression of thyroid gland and related endocrine glands hormonal secretion via the determination of pituitary, iodine-containing hormones, parathyroid hormones and adrenal cortex hormones level in the dynamics of the thyroid gland thermal damage. The author studied the LPS and HAES-LX-5% influence on the pituitary, iodine-containing hormones, parathyroid hormones and adrenal cortex hormones in the rats blood 1, 3, 7, 14, 21 and 30 days after the thyroid gland thermal damage. The author proved the expressed dysfunctions with hormonal disorders throughout the 30 days of the post-burn period. The hypothalamuspituitary-thyroid gland regulatory system hormonal dysfunction together with failed regulatory relationships in the axes of the endocrine system regulation pituitary-parathyroid gland and pituitary-adrenal glands were showed. The hyperosmolar colloidal solutions - LPS and HAES-LX 5% - positive effects were revealed in conditions of the thyroid gland thermal damage aimed to restore the hormonal imbalance. The author concludes about the prospects for thyroid gland burn-induced impaired functional activity restoration taking into account the hyperosmolar colloidal solutions revealed efficacy.