Abstract:
The anti-inflammatory activity of the ointment based on ginger extract was
investigated on carrageenan-induced inflammation.
Methods: Anti-inflammatory activity was investigated on the carrageenan inflammation
model in rat. The animals were divided into 5 groups: first group– control (without treatment);
second group– animals received preventive treatment of ointment with ginger extract two
days before experiment and with subsequent treatment after administration of phlogogen;
3rd group– animals received applications of 5% ibuprofen 2 days before experiment and with
subsequent treatment after induction of inflammation; fourth group – animals were treated
with ginger extract ointment after one day of the phlogogen administration; fifth group –
animals were treated with reference drug after one day of the phlogogen introduction. The
biochemical parameters (concentration of sialic acids, seromucoids, contents of total proteins
and protein fractions) of the blood of experimental animals were investigated.
Results: After local application of the ointment from the ginger extract, under the conditions
of its application after phlogogen inoculation, the effect was the same as anti-inflammatory
effect of the ibuprofen which was used as reference drug. The preventive ointment application
provided faster and more intense reduction of the inflammatory focus with returning to the
background indicators on the eighth day of the experiment, and for biochemical parameters
on the sixth day of therapy.
Conclusion: The ointment from ginger extract shows anti-inflammatory activity by inhibiting
inflammation caused by carrageenan.
