Circadian biorithms of the body and the role of the liver as their peripheral oscillator

Abstract

Biorhythm is one of the laws of the organism, which is characterized by the presence of cyclic oscillations, which ensures the adaptation of the organism to the rhythmic changes of the external and internal environment. That is, biorhythms are the basis of adaptation of the organism to environmental factors and ensure its vital functions. The most important practical value and the most detailed among the biorhythms of the body study circadian rhythms. The liver creates a single metabolic and energy pool of the body for the metabolism of proteins, fats, carbohydrates. Therefore, in turn, the metabolism of proteins, fats, carbohydrates, enzymes, vitamins; regulation of water, mineral and pigment metabolism; activity of excretory and detoxification processes are characterized by circadian dependence of the course. All diseases of the body are accompanied by a violation of the architecture of its circadian rhythm, ie the phenomenon of desynchrony, starting from the cellular level and ending at the highest body level. Knowledge of the functional state of biorhythms of a healthy organism and their changes (desynchrony) in liver pathology is the key to targeted correction of dysregulatory disorders in diseases and optimization of this organ of pharmacotherapy.