Determining the level of stromal and epithelial cells activity in normal and hyperplastic endometrium of late reproductive and perimenopausal women

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dc.contributor.author Chumak, Z. V. en
dc.contributor.author Artyomenko, V. V. en
dc.contributor.author Shapoval, M. V. en
dc.contributor.author Mnih, L. V. en
dc.contributor.author Kozhukhar, G. V. en
dc.contributor.author Derishov, S. V. en
dc.date.accessioned 2023-04-02T16:59:36Z
dc.date.available 2023-04-02T16:59:36Z
dc.date.issued 2023
dc.identifier.citation Determining the level of stromal and epithelial cells activity in normal and hyperplastic endometrium of late reproductive and perimenopausal women / Z. V. Chumak,V. V. Artyomenko, M. V. Shapoval et al. // Journal of medicine and life. 2023. Vol. 16. Is. 2. P. 210–214. en
dc.identifier.uri https://repo.odmu.edu.ua:443/xmlui/handle/123456789/12374
dc.description.abstract Hyperplastic processes of the endometrium (HPE) are a group of benign endometrial and stromal cells that have undergone altered growth. This study aimed to investigate the potential role of hypoxia (as indicated by Hif-1α) and apoptosis markers (p53 and BCL-2) in the development of hyperplastic processes of the endometrium (HPE). Results showed that endometrial cells with atypical hyperplasia had increased levels of Hif-1ɑ, which indicates the presence of endometrial hypoxia and may trigger pathological manifestations. Though this result was not statistically significant, it could be the cause of atypia hyperplasia in the late reproductive period (Hif-1ɑ=1.89±0.09 units) and the perimenopausal period (Hif-1ɑ=2.09±0.07 units). Additionally, the study found that p53 markers were elevated in epithelial cells in the late reproductive period, and similar patterns were observed in the perimenopausal period, with the biggest expression in atypical hyperplasia. The study also found that the high expression of BCL-2 indicator (+++) was less common in late reproductive period women with atypia than those without it (χ2=7.2 p=0.01). A similar situation was observed in women in the perimenopausal period (χ2=4.2 p=0.04). These findings suggest that hypoxia may play a role in the development of HPE, as well as changes in apoptotic markers present in the endometrial tissue. en
dc.language.iso en en
dc.subject hyperplastic endometrial processes en
dc.subject p53 en
dc.subject BCL-2 en
dc.subject carcinogenesis en
dc.subject apoptosis en
dc.subject perimenopausal period en
dc.subject late reproductive period en
dc.title Determining the level of stromal and epithelial cells activity in normal and hyperplastic endometrium of late reproductive and perimenopausal women en
dc.type Article en


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