Efficiency of local application of a new hygienic agent during treatment of radioreactions of oral mucosa in patients with tumors of head and neck region after the radiation therapy

Abstract

The article deals with topical application of a new medication “Apior” gel in the complex therapy of radiation complications in the oral cavity of patients with tumors of head and neck region undergoing radiation treatment. It was proved that the new apigel subsides pronouncement of symptoms of xerostomia and oral radioreactions, arrests them, improves hygienic state of oral cavity, salivation, positively affects nonspecific resistance of oral fluid, rendering a radioprotective action. A positive effect of “Apior” gel is reached due to renewal of balance of pro- and antioxidant activity, reduction of level of pro-inflammatory (i.e., IL-1and IL-6) and rise of anti-inflammatory (i.e., IL-4) cytokines level, restoration of secretory immunoglobulin A, normalizes oral microbiocenosis.