Technological features of extraction of essential oils from the leaves of Ocimum basilicum, development of dosage form and study of its anticonvulsant activity

Abstract

Neuropsychiatric diseases, neuroses – occupy a leading place in the list of common diseases of mankind. Stress, illness, poor diet and unhealthy lifestyles are all the foundations of such diseases. The above determines the relevance of the development and introduction to the market of new drugs aimed at pharmacotherapy and pharmacocorrection of these conditions. The main principle of pharmacocorrection of neuroses is the appointment of sedatives, anxiolytics, of which the best use of herbal medicines, because they have fewer side effects. According to the world health organization (WHO), epilepsy is one of the most common central nervous system (CNS) diseases. Epilepsy is treated with several methods, the main of which is the use of antiepileptic drugs with specific mechanisms of action. One of the promising areas of development of drugs for the treatment of epilepsy is the use of phytotherapeutic agents, which has become the task of our work. It is known that herbal medicines can affect various links in the pathogenesis, have a beneficial effect on the CNS as a whole, which significantly reduces the risk of so-called epileptic personality disorders. The purpose of the study is development of technology for obtaining an essential oil extract from O. basilicum, prediction of „drug-like” activity by in silico methods.