Topical application of the new dental elixir for treatment of periodontal complications during experimental reproduction of the metabolic syndrome

Abstract

The aim of the work was to study the changes in the periodontal tissues of rats with simulation of metabolic syndrome of alimentary genesis and to determine a possibility of their correction with the new dental elixir. Materials and Methods: The study of biochemical changes in the blood serum, liver and gingival tissue was performed during simulation of the metabolic syndrome of alimentary genesis on Wistar rats, all animals were divided into three groups: 1) intact, 2) with simulated metabolic syndrome, 3) with simulated metabolic syndrome after which local therapy with the use of the newly created elixir was applied into gums. Results: Metabolic syndrome simulation causes the increase in body weight and in level of biochemical markers: insulin resistance, hyperglycemia, inflammation, both of the whole organism and periodontal tissues locally, provokes a quantitative increase of opportunistic and pathogenic microflora in the gingival tissues of rats against the background of reduced nonspecific immunity, reduced antioxidant activity and inflammation. The use of the new dental elixir based on bee product and adaptogens of plant origin leads to improvement of inflammatory markers activity level, removes contamination with pathogenic microflora and increases non-specific immunity and antioxidant protection of periodontal tissues. Conclusion: A local application of the new dental elixir for treatment of the inflammatory processes of gingival tissues against a background of the metabolic syndrome simulation has a positive effect on biochemical parameters of periodontal tissues, significantly reducing the triglycerides level, providing anti-inflammatory and antioxidant effects, locally activating functional activity of enzymes of antioxidant defense, non-specific resistance.