Abstract:
We have reported that electrical stimulations of cerebellar structures resulted in the heightened antiseizure effectiveness of diazepam against pentylenetetrazol (PTZ)-kindled seizures. Such effects might be explained by the increased antioxidant mechanisms in
the brain tissue, which counterparts oxidative stress,
as a fundamental pathogenetic mechanism of chronic
epileptic activity. The work aimed to investigate the
state of antioxidant defense in the cerebral cortex of
PTZ-kindled rats under electrical stimulations (100 Hz,
0,25 ms, 50-100 mcA, 2,5 s) of the paleocerebellar cortex
(V-VII lobules).
