Blockade of Н3 histamine receptors facilitates antiseizure action of Pentoxyphilline

Abstract

Considering the important role of inflammation in epilepsy development is reasonable to investigate the effects of combined usage of different modulators of neural inflammation. The work aimed to investigate the effects of the blocker of histamine Н3 pitolisant hydrochloride (Selleck, USA) and pentoxyphilline (Sigma-Aldrich, USA), which prevents proinflammatory cytokines elaboration upon pentylenetetrazol (Sigma-Aldrich, USA) (PTZ)-kindled seizures in rats. Male Wistar rats four months of age kindled to the stage of generalized tonic-clonic seizure fits with PTZ (35 mg/kg, i.p.) were used in observations. Pentoxyphilline (50 mg/kg, i.p.) administered with pitolisant (5 mg/kg, i.p.) caused the increase of first seizure manifestations latency by 67.2% in comparison with the control group of kindled rats (P<0.05).