Blockade of Н3 histamine receptors facilitates antiseizure action of Pentoxyphilline

Prybolovets, K. O.; Poshyvak, O. B.; Pervak, M. P.; Yehorenko, O. S.; Godlevsky, L. S.

dc.contributor.author	Prybolovets, K. O.	en
dc.contributor.author	Poshyvak, O. B.	en
dc.contributor.author	Pervak, M. P.	en
dc.contributor.author	Yehorenko, O. S.	en
dc.contributor.author	Godlevsky, L. S.	en
dc.date.accessioned	2022-12-09T09:11:52Z
dc.date.available	2022-12-09T09:11:52Z
dc.date.issued	2022
dc.identifier.citation	Blockade of Н3 histamine receptors facilitates antiseizure action of Pentoxyphilline / K. O. Prybolovets, O. B. Poshyvak, M. P. Pervak et al // Acta neurobiologia experimentalis: II 12th Neuronus 2022 Neuroscience Forum, 15–17 october 2022, Krakov, Poland. Vol. 82. P. 51.	en
dc.identifier.uri	https://repo.odmu.edu.ua:443/xmlui/handle/123456789/11716
dc.description.abstract	Considering the important role of inflammation in epilepsy development is reasonable to investigate the effects of combined usage of different modulators of neural inflammation. The work aimed to investigate the effects of the blocker of histamine Н3 pitolisant hydrochloride (Selleck, USA) and pentoxyphilline (Sigma-Aldrich, USA), which prevents proinflammatory cytokines elaboration upon pentylenetetrazol (Sigma-Aldrich, USA) (PTZ)-kindled seizures in rats. Male Wistar rats four months of age kindled to the stage of generalized tonic-clonic seizure fits with PTZ (35 mg/kg, i.p.) were used in observations. Pentoxyphilline (50 mg/kg, i.p.) administered with pitolisant (5 mg/kg, i.p.) caused the increase of first seizure manifestations latency by 67.2% in comparison with the control group of kindled rats (P<0.05).	en
dc.language.iso	en	en
dc.subject	histamine receptors	en
dc.subject	Pentoxyphilline	en
dc.subject	epilepsy	en
dc.subject	different modulators of neural inflammation	en
dc.title	Blockade of Н3 histamine receptors facilitates antiseizure action of Pentoxyphilline	en
dc.type	Article	en