Pentylenetetrazole-induced kindling as a model metabolic syndrome

Abstract

Data on the relationship between epilepsy and metabolic syndrome justified the evaluation of MS markers expression in PTZ-kindled rats. PTZ kindling was induced in four months aged male Wistar rats with three weeks epileptogen (35.0 mg/kg, i.p.) administration. Those animals with fully developed generalized seizures were used for investigations. The glucose tolerance test (GTT) was followed by a significant rising in blood glucose level 30 min after glucose i.p. administration (2.0 g/kg) up to 395.7+47.2 mg/dl), which exceeded the control data by 1.74 times (P<0.001). Insulin tolerance test (0.75 U of insulin/kg) revealed in 15 min after glucose i.p. administration (2.0 g/kg) up to 114.3+15.7 mg/dl), which exceed the control data by 31.3% (P<0.001).