The synergy of antiepileptic action of combined usage of neuro-vascular modulators with a wide spectrum of effects upon neuronal tissue

Abstract

Today, about 70 million people worldwide suffer from epilepsy. In Ukraine, the prevalence of epilepsy is about 2.5 - 4.5 per 1000. Despite the emergence of new, more effective antiepileptic drugs (AEDs), 30% of patients are insensitive to AEDs. Pharmacological resistance (AED insensitivity) is defined as the inability to prescribe (sequential or combined) two antiepileptic drugs in adequate doses to eliminate the manifestations of epilepsy. Solving pharmacological resistance requires the rapid development of new antiepileptic drugs and the definition of new strategic approaches to its treatment. Aim of the investigation. To investigate effects of combined administration of rapamycin – blocker of mTOR, pioglitazone – agonist of PPAR-gamma, and minocycline hydrochloride – inhibitor of microglia upon acute seizures in mice.