Therapy with vitamin D metabolits of structural and functional changes in bone tissue of working postmenopausal women with ostearcopenia

Abstract

The prevalence of osteoporosis and vitamin D deficiency in postmenopausal women working under harmful labour conditions has been examined. Reduced bone mineral density was revealed in 85% of the persons under observation, the incidence of OP was 35%, sarcopenia (SP) – 35%. Vitamin D deficiency was foundin 91.3% ofthe workers, at the same time severe VD deficiency was observedin 32.9%, VD deficiency – in 7.5%,and the optimal level of vitamin D was observedin 1.2%of cases. 79 PM women with OP aged 50 – 60 y. o.(meanage – (55.7 ± 0.9) years), working at harmful conditions of the working environment with an average length of service 26.14 ± 0.91years have been examined. Clinical group A (n = 30) received cholecalciferol at a dose of 2000 IU (4 drops) per day and alfacalcidol 1 μg (1 capsule) once a dayfor a year.This resulted in a positive effect on the level of 25(OH)D. Тhe complex appointment of cholecalciferol and alfacalcidol reduced thelevel of PTH and confirmed the role of VD deficiency in the progress of secondary hyperparathyroidism.The data obtained revealed a slowing of the effect of VD onosteoclastogenesis. Decrease of bone resorption marker CTx in the women under examination confirmed the latter.