Changes in vasoconstructor-vasodilation potential of vessels in experimental antiphospholipid syndrome

Abstract

As a result of our study, the development of endothelial dysfunction in experimental antiphospholipid syndrome is confirmed: an increase in the marker of ED (endothelin-1) and a pathological increase in vasoconstrictor potential on the background of weakening of vasodilatation. There was a pathological increase in the vasoconstrictor potential of blood vessels in animals simulated antiphospholipid syndrome, as evidenced by an increase in endothelin-1 levels in the blood of rats (p <0,001). Violation of nitric oxide synthesis was detected against the background of the development of experimental antiphospholipid syndrome, which is confirmed by a marked decrease in the level of Snitrosothiols. The most pronounced normalization of vasoconstrictor-vasodilatory potential of vessels was found in rats, whose simulated antiphospholipid syndrome was corrected with warfarin, immunoglobulin and L-arginine solution.