Bacterial dysbiosis risk prediction according to vaginal normobiota indicator

Abstract

Vaginal bacterial dysbiosis is evident by the progressive growth of obligate and optional anaerobic bacteria, myco- and ureaplasmas and fungi against the background of a sharp decrease in the number of lactobacilli. The aim of those work was to establish prognostic factors and the risk of bacterial dysbiosis development according to the vaginal normobiota indicator based on the comprehensive analysis of the state of systemic and local immunity and hormonal regulation. As conclusions, with bacterial dysbiosis the pathological regulatory hormonal-immune system is formed, which contributes to the vaginal dysbiosis progression. In accordance with this, dysbiosis can be considered as a dysregulatory pathology, and the identified indicators of the “interleukin cascade” as its markers.