Excessive accumulation of candidate gene polymorphisms in young hypertensive patients as a factor of increasing incidence of arterial hypertension at a young age

Abstract

The concept of accumulation of candidate genes (CG) polymorphisms in the realization of the hypertensive phenotype is perspective both in understanding about the arterial hypertension (AH) formation as a disease with a constant increasing incidence, and in prognosis and early prevention. The purpose of the research was to check the hypothesis of excessive accumulation of genetic polymorphisms in young hypertensive patients compared with older hypertensive patients and non-hypertensive patients as a factor of the increasing morbidity of AH at a young age in the modern population. The prevalence of AH-associated polymorphisms in these groups was studied with the calculation of gene modification index (GMI).