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Recent submissions

Видання іноземною мовою. Кафедра фізіології та біофізики: Recent submissions

Now showing items 41-60 of 86

The synergy of Antiepileptic action of Rapamycin, Pioglitazone, and Minocycline on acute seizures in mice

Prybolovets, K. O.; Pervak, M. P.; Al-Nadawi, N.; Liashenko, A. V.; Poshyvak, O. B.; Godlevsky, L. S. (2022)

One-third of patients with epilepsy are resistant to antiepileptic drugs (AED). Combined treatment with neuromodulators with antiserizure action, which are not classical AED, is promising for searching for more effective ...
The synergy of antiepileptic action of combined usage of neuro-vascular modulators with a wide spectrum of effects upon neuronal tissue

Poshyvak, O. B.; Pinyazhko, O. R.; Abumutair, Sh. N.; Pervak, M. P.; Yehorenko, O. S.; Godlevsky, L. S. (2022)

Today, about 70 million people worldwide suffer from epilepsy. In Ukraine, the prevalence of epilepsy is about 2.5 - 4.5 per 1000. Despite the emergence of new, more effective antiepileptic drugs (AEDs), 30% of patients ...
Enhancement of the anticonvulsant effect of the h3 histamine receptor blocker thioperamid against the use of pioglitazone

Yehorenko, O. S.; Pervak, M. P.; Poshyvak, O. B.; Liashenko, A. V.; Godlevsky, L. S. (2022)

The purpose of the study was to study the dynamics of foci of epileptic activity, which were reproduced in the cerebral cortex of kindled rats using the sodium salt of benzylpenicillin, under the conditions of individual ...
The influence of immunodeficiency on the level of CD34-positive cells in the cervix

Gargin, V.; Volokhova, H.; Koshelnyk, O.; Gulbs, O.; Kachailo, I.; Lytvynenko, M. (2022)

There are many studies on changes in cervix, however, there are no data about property of cervical tissue to keep potential for regeneration under influence of immunodeficiency, which is very important since it allows ...
Oxidative stress suppression contributes to antiseizure action of axitinib and rapamycin in pentylenetetrazol-induced kindling

Poshyvak, O. B.; Pinyazhko, O. R.; Godlevsky, L. S. (2021)

Rapamycin and axitinib block different kinases in signaling pathways such as PI3K-Akt-mTOR and BDNF-TrkB, respectively. Both have antiseizure and antioxidative actions, which justify studying the combined effects of these ...
Oxidative stress suppression contributes to antiseizure action of axitinib and rapamycin in pentylenetetrazol-induced kindling

Poshyvak, O. B.; Pinyazhko, O. R.; Godlevsky, L. S. (2021)

Rapamycin and axitinib block different kinases in signaling pathways such as PI3K-Akt-mTOR and BDNF-TrkB, respectively. Both have antiseizure and antioxidative actions, which justify studying the combined effects of these ...
Axitinib displays antiseizure activity on pentylenetetrazol – induced kindling mode

Poshyvak, O. B.; Pinyazhko, O. R.; Godlevsky, L. S. (2021)

This work aimed to investigate the effects of a specific inhibitor of vascular endothelial growth factor receptor generic axitinib upon pentylenetetrazol (PTZ) - induced kindled and acute convulsions and to compare ...
Influence of transcranial magnetic stimulation on spike-wave discharges in a genetic model of absence epilepsy

Godlevsky, L. S.; Kobolev, E. V.; van Luijtelaar, E. L. J. M.; Coenen, A. M. L.; Stepanenko, K. I.; Smirnov, I. V. (2006)

Transcranial magnetic stimulation (TMS) impulses, (0.5 Hz, 3 impulses) were presented at threshold intensity to male WAG/Rij rats. One group received stimuli, which involved motor responses of hindlimbs, rats of the second ...
Diazepam and electrical stimulation of paleocerebellar cortex inhibits seizures in pentylenetetrazol kindled rats

Godlevsky, L. S.; Shandra, O. O.; Pervak, M. O.; Shandra, A. A. (2020)

The cerebellum is a potent anti‑epileptic target for deep brain stimulation in patients with drug‑resistant epilepsy. The effects of such stimulation, however, may also favor seizure activity. Our goal was to investigate ...
Cumulative cardiotoxic effect of bleomycin in experiment

Gozhenko, A.; Bestanchuk, O.; Kaschenko, O.; Narbutova, T. (2021)

The aim of the study was to evaluate the cumulative toxic effect of bleomycin under experimental conditions Material and Methods. The study was conducted in the Research Institute of Transport Medicine during 2016-2021. ...
Cardiotoxic effect of bleomycin with a single administration in the experiment

Bestanchuk, E.; Gozhenko, A.; Kashchenko, O.; Narbutova, T.; Berezovskyi, O.; Zаkharova, V. (2021)

The aim of the study was to evaluate the effect of a single injection of bleomycin on the heart Material and methods. The study was conducted in the Research Institute of Transport Medicine during 2016-2021. The experimental ...
Physiology

Moroz, V. M.; Shandra, O. A.; Vastyanov, R. S.; Yoltukhivsky, M. V.; Omelchenko, O. D. (2020)

"Physiology" is a textbook on Human Physiology, written in English for best underdstanding of physiology by English-speaking students, contains basic educational materials according to the Physiology Course Program. The ...
Physiology

Moroz, V. M.; Shandra, O. A.; Vastyanov, R. S.; Yoltukhivsky, M. V.; Omelchenko, O. D. (2016)

"Physiology" is a textbook on Human Physiology, written in English for best underdstanding of physiology by English-speaking students, contains basic educational materials according to the Physiology Course Program. The ...
Anti-Inflammatory Effect of Semisolid Dosage Forms Containing Capsaicin

Boiko, Yu. A.; Kravchenko, I. A.; Mohammad Ayat; Shandra, A. A. (2016)

Capsaicin is alkaloid found primarily in the fruit of the Capsicum genus. Capsaicin and its analogues have been used in topical creams and patches to treat chronic pain and inflammation. Objectives: The paper deals with ...
Study of anti-inflammatory effect of liquid Capsicum annuum L. extracts in specific and nonspecific adjuvant-induced arthritis

Boiko, Yu. A.; Ayat, M.; Boiko, I. A.; Shandra, A. A. (2021)

The work is devoted to studying the anti-inflammatory properties of carotenoids extracted from the Capsicum annuum L. fruits. Such a choice is due to their high antioxidant activity and membranestabilizing effect. Of ...
The study of the anti-inflammatory properties of carotenoid liquid extracts on the model of adjuvant-induced inflammation

Boiko, Yu.; Ayat, M.; Boiko, I.; Shandra, A. (2021)

The search for new anti-inflammatory substances is an important area of pharmacology. Plant carotenoids have many positive biological effects and are of interest as potential anti-inflammatory agents. The aim. To study the ...
Effects of cerebellar transcranial direct current stimulation upon kindled seizures depends upon PPARγ modulation

Pervak, M.; Godlevsky, L. (2019)

The purpose of the investigation was to estimate the effectiveness of peroxisomal proliferator-activated γ-receptors (PPARγ) modulation upon the antiseizure effects of transcranial direct current stimulation (tDCS). In ...
On the mechanism of antiseizure effect engendered with nucleus dentatus stimulation

Pervak, M.; Godlevsky, L. (2019)

Via sodium salt penicillin solution (10.000 IU/ml) application upon posterior right sygmoid gyrus epileptic foci have been created in anaesthetized, myorelaxed and artificially ventilated cats. Electrical stimulations (ES) ...
Effects of Electrical Stimulation of the Cerebellum and Injections of Levetiracetam on Aggressive Behavior of Kindling Rats

Muratova, Т. М.; Godovan, V. V.; Godlevsky, L. S.; Kobole, E. V. (2014)

In rats with the corazole-induced kindling syndrome, we estimated the conditions for the appearance of battles on an electrified floor; the threshold for initiation of aggressive reactions in kindling animals was lower, ...
Information System for Early Diabetic Retinopathy Diagnostics based on Multiscale Texture Gradient Method

Godlevsky, L. S.; Kresyun, N. V.; Martsenyuk, V. P.; Shakun, K. S.; Tatarchuk, T. V.; Prybolovets, K. O.; Kalinichenko, L. F.; Karpinski, M.; Gancarczyk, T. (2020)

Structures of eye bottom were extracted using multiscale texture gradient method and color characteristics of macular zone and vessels were verified in CIELAB scale. The difference of average values of L*, a* and b* ...

Now showing items 41-60 of 86

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