Oxidative stress and lipid peroxidation in experimental peritonitis

Abstract

Peritonitis is one of the most serious complications of pathology of the abdominal organs, which is characterized by a high mortality rate. Violation of the natural mechanisms of detoxification (immune, detoxification functions of the liver and kidneys), which occur in acute peritonitis, due to primary damage to their structure and the development of maladaptation mechanisms, accompanied by endogenous intoxication syndrome. One of the characteristic and aggravating manifestations of the syndrome of endogenous intoxication is the activation of lipid peroxidation (LPO). The aim: study of the dynamics of primary and secondary products of lipid peroxidation in experimental peritonitis. In the first hour simulated fecal peritonitis development in the rats blood revealed an increase in the level of diene conjugates and malondialdehyde (p <0.001 compared with the results of intact animals. In the second stage was detected more pronounced increase in the level of primary and secondary products of lipid peroxidation (p <0.001) as compared with the data of the same hole in the first stage, and compared with the results of group No. 1. On the 3rd day of simulated peritonitis development in rats there is a marked deterioration of the animal condition, which was manifested in lipid peroxidation progression: the diene conjugates level increased at the significance level p <0.001, and the level of malondialdehyde compared to p <0.05 data from the previous stage of the same group.