Abstract:
Currently, one of the most common problems in childhood are urinary tract infections (UTI). The recurrent UTI is the risk of irreversible damage to the renal parenchyma, replacing it with connective tissue and a further outcome in chronic kidney disease (CKD). The aim of the study: to study the effectiveness of immunovaccination in the complex anti-relapse therapy in children with urinary tract infection. Materials and methods. The study involved 70 patients who were hospitalized at the City Children's Hospital Academician B. Ya. Reznik. In the dynamics of the observations conducted a general analysis of blood and urine, bacteriological examination of urine, if necessary, Rg-urological examination. In the period of acute UTI, all patients received treatment according to the International European Recommendations. For the prevention of UTI, uroseptic (nitrofuran) was used in prophylactic regimens in combination with a lyophilized preparation. Results. In the course of anti-relapse treatment, there was a decrease in the number of recurrences of the disease in children after completing the course in 39 of 70 patients, which amounted to 55.71% and clinical and laboratory remission of UTI was achieved. The number of relapses with a microbial number ≥105 was significantly reduced (from 5.21 to 2.36, p<0.05). The number of relapses with a bacteriuria level of >104 CFU also decreased. At the time of the survey in the first control point (after 3 months), a decrease in the microbial number was noted in 37.14%, and in the control after 6 months – in 52.86%. The recurrence rate of UTI for the 6-month period decreased from 3.38±0.48 to 1.67±0.24 times a year. The obtained effect allowed reducing the use of antimicrobial agents in 34.3% of patients. At the same time, the effectiveness of antimicrobial therapy has increased.
Conclusion. Thus, the results of our studies showed a high efficacy of vaccine prophylaxis using
lyophilized preparations for UTI in children, which can be used to prevent the occurrence of relapses. A reduction in the frequency of relapses and the need to use antibacterial drugs, sanitation of urine and the absence of side effects during vaccination have been established. All human studies were conducted in compliance with the rules of the Helsinki Declaration of the World Medical Association "Ethical principles of medical research with human participation as an object of study". Informed consent was obtained from all participants.
