Дослідження показників про- та антиоксидантної системи в спермоплазмі при порушенні фертильності у чоловіків

Abstract

Одним з важливих показників погіршення стану репродуктивного здоров'я населення э безплідність, від якої страждають близько 15 % подружніх пар. Упродовж останніх років в Україні щорічно реєструється майже 11 тис. випадків даної патології у чоловіків. Мета дослідження: вивчення стану про- та антиоксидантних систем в спермоплазмі при порушенні фертильності у чоловіків з різними видами чоловічого безпліддя.

The article presents the study results of marker indicators of pro- and antioxidant spermoplasm systems among men of reproductive age with various types of infertility. It is shown that patients who were diagnosed with “secretory male infertility”, had the level of MDA content that was exceeding control indicators in 1.2 times (α≤0,05) with simultaneous activation of SOD (in 132.2%, α≤0,05) against the background of slight CAT activity decreasing. The SOD/CAT ratio increased in 1.44 times compared to the control, and the activity of GAOS enzymes was not significantly different from the control group. The condition of pro- and antioxidant protection system can be classified as “activated” due to “SOD + CAT” link with imbalance in the system, which can lead to progression of cytotoxic effects. The patients’ segmentation who were diagnosed with “excretorytoxic male infertility” into three subgroups by MDA content in spermoplasm made it possible to establish that the first subgroup was characterized by “compensatory activation” mainly of GAOS against the background of decreasing MDA content, in the second subgroup - indicators of the pro- and anti-radical protection system did not have reliable differences comparing with control results. The third subgroup showed increase of MDA content (66.1%, α≤0,01) and activity decrease of all anti-radical protection systems. The state of pro- and antioxidant protection system in this subgroup can be classified as “oxidative stress.” The indicators study of pro-antioxidant systems in spermoplasm among patients with various types of male infertility will allow to carry out pathogenetically justified prevention and correction of conditions, which are accompanied by development of oxidative stress.