The tumor immune contexture and DNA repair enzymes expression in gastric carcinoma

Abstract

Tumor immune microenvironment (TIME) assessment is thought to be effective tool for evaluation of tumor-host interplay and prognostication of different cancers, including gastric carcinoma (GC). As inflammatory signaling is closely related with DNA-repair pathways, there could be the link between GC immune contexture and theranostic markers expression defining GC response to different therapies. This study aimed to clarify the relations between TIME and expression of ERCC1, TOPO2A and PDL1 in GC of different histological types.