https://repo.odmu.edu.ua:443/xmlui/handle/123456789/925 Fri, 14 Aug 2026 12:17:19 GMT 2026-08-14T12:17:19Z https://repo.odmu.edu.ua:443/xmlui/handle/123456789/20201 Impact of sodium bicarbonate, boric, medium mineralization highly carbonated water and ciprofloxacin combination on the some upper respiratory tract microbiota biofilm architecture Rusakova, M.; Gushcha, S.; Sierpińska, L.; Koieva, Kh.; Andreev, A.; Yamborko, G. The use of irrigation therapy as an adjunctive treatment for upper respiratory tract infections is attracting interest. This is particularly notable when the effectiveness of conventional antibiotic therapy is reduced. The aim of this study is investigation of effects of sodium bicarbonate, boric, medium mineralization highly carbonated water, alone and in combination with Ciprofloxacin, on the architecture and intensity of biofilm formation by representative upper respiratory tract microbiota. Materials and Method. Multispecies biofilms consisting of Lactobacillus sporogenes co-cultured with Escherichia coli ATCC 25922 or Staphylococcus aureus ATCC 25923 were used as experimental models. Biofilm formation was quantified using crystal violet staining and spectrophotometric analysis, while structural characteristics were assessed by light microscopy and morphometric image analysis. Results. Ciprofloxacin at minimum inhibitory concentrations significantly increased biofilm biomass and coverage in both microbial consortia, indicating antibiotic-induced biofilm enhancement. Treatment with mineral water alone reduced total biofilm area and coverage, but promoted fragmentation into a greater number of discrete microcolonies. Conclusions. Mineral water modulates biofilm cohesion and spatial organization rather than solely reducing microbial viability. The study demonstrates the potential of mineral water as an adjunctive agent to enhance antibiofilm efficacy in the management of antibiotics in upper respiratory tract infection. Thu, 01 Jan 2026 00:00:00 GMT https://repo.odmu.edu.ua:443/xmlui/handle/123456789/20201 2026-01-01T00:00:00Z https://repo.odmu.edu.ua:443/xmlui/handle/123456789/20091 Successful treatment of recurrent ear keloid with intrascar cryosurgery Pukhlik, S.; Andreev, A.; Tagunova, I.; Plakida, A.; Gushcha, S. Keloid scars are pathological fibroproliferative lesions characterized by excessive collagen deposition and abnormal wound healing. Auricular and postauricular keloids represent a particularly challenging clinical problem because of their high recurrence rates, cosmetic significance, and the tendency toward progressive enlargement following repeated surgical interventions. Intralesional cryosurgery has emerged as a tissue-preserving therapeutic option aimed at selective destruction of pathological scar tissue while minimizing damage to surrounding structures. Thu, 01 Jan 2026 00:00:00 GMT https://repo.odmu.edu.ua:443/xmlui/handle/123456789/20091 2026-01-01T00:00:00Z https://repo.odmu.edu.ua:443/xmlui/handle/123456789/20026 Role of nasopharyngeal status in the treatment of type 2 primary diffuse chronic rhinosinusitis in adult patients Pukhlik, S. M.; Yevchev, F. D.; Diedykova, I. V.; Titarenko, O. V.; Hruzevskyi, O. A.; Levina O.O.; Пухлік, С. М.; Євчев, Ф. Д.; Дєдикова, І. В.; Тітаренко, О. В.; Грузевський, О. А.; Левіна, О. О. The study was devoted to evaluating the role of the nasopharyngeal zone in the course and treatment of type 2 primary diffuse chronic rhinosinusitis in adults. A total of 339 patients were examined, of whom 68 (20.06 %) had concomitant chronic nasopharyngitis. At the second stage, 58 patients with chronic nasopharyngitis and 91 patients without it received standard therapy supplemented with the mucosal bacterial vaccine Lantigen B, whereas 36 control patients received standard treatment alone. Clinical, videoendoscopic, functional, microbiological, and immunological assessments were performed. Patients with chronic nasopharyngitis more frequently demonstrated grade I adenoid vegetations, greater clinical severity, pronounced nasopharyngeal dysbiosis, and middle-ear involvement. The addition of Lantigen B resulted in a significantly greater reduction in symptoms, normalization of the nasopharyngeal microbiome and secretory IgA levels in oropharyngeal secretions, and a lower incidence of acute otitis media and otitis media with effusion, particularly in patients with concomitant chronic nasopharyngitis; Дослідження було присвячене оцінці ролі стану назофарингеальної зони у перебігу та лікуванні первинного дифузного хронічного риносинуситу типу 2 у дорослих. Обстежено 339 пацієнтів, серед яких у 68 (20,06 %) діагностовано супутній хронічний назофарингіт. На другому етапі 58 пацієнтів із хронічним назофарингітом та 91 пацієнт без нього отримували стандартну терапію з додаванням мукозальної бактеріальної вакцини Лантіген Б; 36 пацієнтів контрольної групи отримували лише стандартне лікування. Застосовували клінічне, відеоендоскопічне, функціональне, мікробіологічне та імунологічне дослідження. У пацієнтів із хронічним назофарингітом частіше виявляли аденоїдні вегетації І ступеня, тяжчі клінічні прояви, виражений дисбіоз та ураження середнього вуха. Додавання Лантігену Б забезпечувало достовірніше зменшення симптомів, нормалізацію мікробіому назофарингеальної зони і рівня секреторного IgA у ротоглотковому секреті та зниження частоти гострого середнього і секреторного отиту Thu, 01 Jan 2026 00:00:00 GMT https://repo.odmu.edu.ua:443/xmlui/handle/123456789/20026 2026-01-01T00:00:00Z https://repo.odmu.edu.ua:443/xmlui/handle/123456789/19445 Clinical manifestations of different etiopathogenetic variants of chronic nasopharyngitis Pukhlik, S. M.; Zaporozhchenko, P. O.; Shnaider, S. A.; Пухлік, С. М.; Запорожченко, П. О.; Шнайдер, С. А. The study was devoted to evaluating the clinical manifestations of different etiopathogenetic variants of chronic nasopharyngitis in children, depending on the predominant trigger factors of exacerbations under different associated conditions of the nasopharyngeal zone. A total of 214 children with confirmed chronic nasopharyngitis were divided into three groups: 62 with isolated chronic nasopharyngitis, 41 with chronic nasopharyngitis associated with pharyngeal tonsil hypertrophy, and 111 with chronic nasopharyngitis associated with allergic rhinitis. The comparison group included 35 children with recurrent respiratory infections and complete recovery between episodes. Retrospective and prospective assessment, clinical examination, videoendoscopic otorhinolaryngological evaluation, allergological testing, cytological analysis, and microbiological study of nasopharyngeal mucus were performed. Children with isolated chronic nasopharyngitis most commonly demonstrated frequent acute viral rhinosinusitis followed by prolonged bacterial activation; those with pharyngeal tonsil hypertrophy showed bacterial predominance in both disease periods; and those with allergic rhinitis exhibited viral-allergic exacerbations with allergic-bacterial persistence between exacerbations; Дослідження було присвячене оцінці клінічних проявів різних етіопатогенетичних варіантів хронічного назофарингіту у дітей залежно від переважаючих факторів, що провокують загострення, при різних супутніх захворюваннях назофарингеальної зони. Усього 214 дітей з підтвердженим хронічним ринофарингітом було розділено на три групи: 62 з ізольованим хронічним ринофарингітом, 41 з хронічним ринофарингітом, асоційованим з гіпертрофією глоткових мигдаликів, та 111 з хронічним ринофарингітом, асоційованим з алергічним ринітом. До контрольної групи увійшли 35 дітей з рецидивуючими респіраторними інфекціями та повним одужанням між епізодами. Було проведено ретроспективну та проспективну оцінку, клінічне обстеження, відеоендоскопічне отоларингологічне дослідження, алергологічне тестування, цитологічний аналіз та мікробіологічне дослідження слизу носоглотки. У дітей з ізольованим хронічним ринофарингітом найчастіше спостерігалися часті гострі вірусні риносинусити, за якими слідувала тривала бактеріальна активація; у дітей з гіпертрофією глоткових мигдаликів у обох періодах захворювання переважали бактерії; а у дітей з алергічним ринітом спостерігалися вірусно-алергічні загострення з алергічно-бактеріальною персистенцією між загостреннями Thu, 01 Jan 2026 00:00:00 GMT https://repo.odmu.edu.ua:443/xmlui/handle/123456789/19445 2026-01-01T00:00:00Z https://repo.odmu.edu.ua:443/xmlui/handle/123456789/18201 The influence of clinical and diagnostic parallels of resistant nasopharyngeal obstruction in patients with dento-maxillofacial anomalies on treatment tactics Diedykova, Iryna If we refer to otorhinolaryngological pathology with nasopharyngeal obstruction and the development of DMA in children and adolescents as a comorbid condition, the relevance of the issue of comprehensive and timely qualified treatment, including surgical treatment, depending on the cause of the development of MB, becomes clear. The situation forces scientists to propose a more detailed consideration of issues of differential diagnosis of otorhinolaryngological pathology to improve treatment and improve the prognosis for the patient, especially in conditions of a time-limited growth period. Wed, 01 Jan 2025 00:00:00 GMT https://repo.odmu.edu.ua:443/xmlui/handle/123456789/18201 2025-01-01T00:00:00Z https://repo.odmu.edu.ua:443/xmlui/handle/123456789/17482 Development of medical education in the context of European integration Аndreev, O. V.; Таgunova, I. K.; Gushcha, S. G.; Volyanska, V. S.; Ivchenko, N. A. European countries are united in their views on the value of human life, education, and healthcare through intellectual, cultural, and social proximity. Human health is the most sensitive issue for different population segments and is often exploited by political forces to create social instability. The European Union is a complex structure that unites member countries with their long-established views on healthcare. An important innovation of today is the introduction of digital technologies into the healthcare system. The events of recent years (pandemic, economic instability, war) have exposed the heterogeneity of European countries' economic and technological levels and changed the proportional possibilities of individual states' contributions to a single system. To create a single, coordinated intellectual space, it is necessary to create a single level of quality of higher education in the countries participating in this space. Strengthening cooperation between Ukrainian scientific and industrial organizations with their partners in the EU, expanding the research space, will serve as an incentive for Ukrainian scientists not only to comply with the agreed rules, but also to actively, equally participate in the improvement and development of new recommendation and regulatory documents of European educational and research spaces, and to make the most of the opportunities of our scientists, teaching staff, and young specialists Wed, 01 Jan 2025 00:00:00 GMT https://repo.odmu.edu.ua:443/xmlui/handle/123456789/17482 2025-01-01T00:00:00Z https://repo.odmu.edu.ua:443/xmlui/handle/123456789/17342 Elective disciplines in the Otolaryngology cycle – a method for improving the applicant’s knowledge Аndreev, O. V.; Tagunova, I. K.; Gushcha, S. G.; Plakida, O. L.; Ivchenko, N. A. Family practice physicians often encounter recurrent upper respiratory tract pathology. The physician's training involves mastering a course in otolaryngology. Still, this course lacks the necessary detailing concerning age-related features of various structures of the upper respiratory tract, congenital pathology in children, and interdisciplinary issues. The topics of selective disciplines are devoted to detailing highly specialized issues. Elective disciplines in the Otorhinolaryngology cycle are chosen not only by students - future otolaryngologists but also by potential doctors of family medicine, therapy, and pediatrics since the prevalence of ENT pathology among therapeutic and pediatric patients is very high. Therefore, introducing elective disciplines for applicants' interest and practicing doctors of related specialties, forming their professional level, is fully justified Wed, 01 Jan 2025 00:00:00 GMT https://repo.odmu.edu.ua:443/xmlui/handle/123456789/17342 2025-01-01T00:00:00Z https://repo.odmu.edu.ua:443/xmlui/handle/123456789/16869 The impact of different types of anaesthesia on the course oftonsillectomy surgery Kolesnichenko, V. Recurrent tonsillitis is considered to be one of the most common ENT diseases. Tonsillectomy as a method of recurrent tonsillitis' treatment is being performed as usual as 20% of all surgeries in ENT departments. The critical criteria for the success of tonsillectomy for the surgeon are the frequency of perioperative complications, long-term results of treatment, and the patient's recovery time. For the patient, those criteria are the severity of pain, psychoemotional stress, the time spent in the hospital, and how quickly he can return to his daily life routine. The factors that significantly affect the outcome of tonsillectomy are the choice of anaesthetic management. Our study aimed to optimise the approach to choosing between endotracheal anaesthesia and local anaesthesia. Clinical studies were made among 158 patients with recurrent tonsillitis who underwent a bilateral tonsillectomy. The patients were divided into two groups. The first group consisted of 97 patients undergoing tonsillectomy using local anaesthesia. The control group included 61 patients undergoing tonsillectomy using endotracheal anaesthesia. We considered the factors such as duration of surgery, the amount of blood loss, intraoperative events, number of incidents of primary and secondary bleeding, assessment of pain syndrome, necessity of analgesics administration, length of hospital stay, and recovery period. Conclusions: tonsillectomy surgery using local anaesthesia requires less time to perform, has lessblood loss, fewer intraoperative events, and fewer incidents of primary and secondary bleeding. The average level of pain is higher in patients using endotracheal anaesthesia. Sun, 01 Jan 2023 00:00:00 GMT https://repo.odmu.edu.ua:443/xmlui/handle/123456789/16869 2023-01-01T00:00:00Z https://repo.odmu.edu.ua:443/xmlui/handle/123456789/15944 Diagnostic signs of malignant negotiations of the skin of the external nose and ear Puhlik, S.; Titarenko, O. The problem of diagnosing malignant diseases of the skin of the face and trunk worries many researchers because of the increase the number of patients with malignant neoplasms of the skin, not only of the face, but also of the body in recent years. Sun, 01 Jan 2023 00:00:00 GMT https://repo.odmu.edu.ua:443/xmlui/handle/123456789/15944 2023-01-01T00:00:00Z https://repo.odmu.edu.ua:443/xmlui/handle/123456789/15579 Study of the effect of a drug from the macromycetes Ganoderma lucidum on the phagocytic activity of peripheral blood neutrophils in patients with year-round allergic rhinitis Bohdanov, V. K.; Gushcha, S. G. Modern complex therapy of patients with persistent (year-round, chronic) allergic rhinitis (AR), based on the use of antihistamines and intranasal glucocorticosteroids, in many cases is not effective enough, since drug therapy acts only on individual links in the pathogenesis, without preventing the progression of the allergic disease. At the same time, the quantitative and reserve capabilities of neutrophil granulocytes are depleted, which increases the level of antigenic load in patients with AR. The aim of this study is to investigate the phagocytic activity of neutrophils in patients with AR who received basic therapy and patients who received basic therapy and a course of the drug from the macromycetes Ganoderma lucidum "Astmagan". We examined 40 patients of both sexes with AR, the duration of the disease ranged from 6 months to 2 years. Patients were divided into 2 equal groups: The 1st group consisted of patients who received basic therapy (oral Loratadine and intranasal Nasonex). The 2nd group consisted of patients who received basic therapy and a course of "Astmagan". The treatment course lasted 90 days. The control group consisted of 25 healthy individuals. After the treatment, patients in both groups showed a statistically significant positive dynamics of phagocytic system activity: in group 1, the phagocytic index (FI) increased by 30 % (p=0.001), in the second group this indicator reached the normal level. Also, in patients of group 1, the phagocytic number (PN) increased by 35 % (p=0.0001), but did not reach the normal level. According to the results of comparative evaluation, a greater efficacy of the treatment complex with the additional use of "Astmagan" was established, which is manifested in the restoration of phagocytic activity of peripheral blood neutrophils, the effect persists for 6 months after treatment. Mon, 01 Jan 2024 00:00:00 GMT https://repo.odmu.edu.ua:443/xmlui/handle/123456789/15579 2024-01-01T00:00:00Z