Видання іноземною мовою. Кафедра внутрішньої медицини №1

Influence of oxidative stress caused by a blast wave in acoustic barotrauma on the auditory analyzer

2026-05-22T07:27:09Z

Influence of oxidative stress caused by a blast wave in acoustic barotrauma on the auditory analyzer Rzhevska, O.; Troian, V.; Sinaiko, I.; Lobova, O.; Solomko, O.; Zolotarovа, K.; Shtrakh, K. Aim: To determine the intensity of posttraumatic oxidative stress (OS) in patients with mild explosive traumatic brain injury (METBI) complicated by acoustic barotrauma and its association with sensorineural hearing loss (SHL) occurrence. Materials and Methods: This study included 43 patients with METBI form October 2023 to May 2024. Results: METBI initiated an increase in OS markers in blood: aldehyde phenylhydrazone (APH) by 53.54% (p<0.05), carboxy phenylhydrazone (CPH) - by 50.51% (p<0.05) and with a deficiency of the antioxidant system of reduced glutathione by 47.4% (p<0.05), total thiols by 61.7% (p<0.05), decrease in the level of nitric oxide in blood by 54.22% (p<0.05), which led to microcirculatory disorder. A direct correlation was established between the frequency of SHL and an increase of APH (r=+0.72, p<0.05), CPH (r=+0.66, p<0.05) and an inverse correlation with a reduced glutathione deficiency (r=-0.85, p<0.05). Conclusions: An imbalance of antioxidant protection led to significant microcirculatory disorders. The data obtained are important for the neutralization of the effect of damaging factors of OS on thе inner ear microcirculation.

Development and Initial Validation of the Novel Computational Method for Dynamic Intracardiac Blood Flow Evaluation

2026-05-05T10:19:37Z

Development and Initial Validation of the Novel Computational Method for Dynamic Intracardiac Blood Flow Evaluation Volkov, D.; Skoryi, D.; Batsak, B.; Karpenko, Iu.; Alamjeet Kaur Sidhu; Carola Gianni; Vincenzo Mirko La Fazia; Bryan MacDonald; Joseph Gallinghouse; Rodney Horton; Sanghamitra Mohanty; Andrea Natale To develop and preliminarily evaluate a practical Python-based program for dynamic intracardiac blood flow visualization and the extraction of new quantitative parameters, serving as an initial step toward future flow-based cardiac evaluation. Methods: The method was technically explored across five imaging modalities (angiography, MRI, ICE, TEE, TTE) using standard diagnostic hardware. Preliminary testing used ECG-gated ICE DICOM images from sixteen patients undergoing first-time AF ablation. Results: The program produced dynamic full-chamber flow visualizations and automatically computed two image-derived surrogate markers of flow-pattern behavior, the *turbulence index (TI)* and *blood mobility fraction (BMF)*, across cardiac cycles. Distinct preliminary flow patterns were observed between sinus rhythm and atrial fibrillation. Outputs are exportable for AI analysis. Conclusions: This proof-of-concept approach demonstrates feasibility for routine intracardiac flow assessments, and introduces TI and BMF as potential flow-based biomarkers for future prognostic use after additional validation.

Modern aspects of knee joints degenerative-dystrophic lesions pathogenesis as a basis for conservative treatment

2026-01-29T11:48:54Z

Modern aspects of knee joints degenerative-dystrophic lesions pathogenesis as a basis for conservative treatment Pidvalnyuk, V. V.; Zolotaryova, N. A.; Shepitko, K. V.; Dzygal, O. F.; Lapshin, D. Ye.; Vastianov, M. R.; Підвальнюк, В. В.; Золотарьова, Н. А.; Шепітько, К. В.; Дзигал, О. Ф.; Лапшин, Д. Є.; Вастьянов, М. Р. Метою дослідження було з’ясування основних патофізіологічних механізмів дегенеративно-дистрофічного ураження суглобів з метою визначення лікувальних заходів, спрямованих на покращення функціонування суглобів та відновлення повноцінного живлення внутрішньосуглобної хрящової тканини. У цьому огляді досліджено сучасні етіологічні чинники та патофізіологічні механізми дегенеративно-дистрофічних та запальних уражень великих суглобів нижніх кінцівок з точки зору обґрунтування доцільності застосування лікувальної тактики пролотерапії гіпертонічними розчинами глюкози та/або декстрози. Систематичний аналіз досліджень з 2020 по 2025 роки, взятих з медичних баз даних PubMed, Google Scholar, Web of Science and SCOPUS засвідчує складність та каскадність патофізіологічних механізмів остеоартрозу, що суттєво ускладнює клінічний перебіг захворювання і робить малоефективною медикаментозну терапію. Автори акцентують увагу на пролотерапії – методиці регенеративної медицини, застосування якої шляхом введення в пошкоджені ділянки колінного суглобу області гіпертонічні розчини глюкози та/або декстрози забезпечує усунення хронічного болю та стимулює природне відновлення внутрішньосуглобних тканин. Клінічні дані підтверджують ефективність пролотерапії у зниженні болю та покращенні рухливості, забезпечуючи кращі результати порівняно з традиційними методами лікування. Автори висловлюють альтернативну важливість пролотерапії для хворих на гонартроз, які шукають неінвазивні варіанти лікування захворювання.; The purpose of the study was to provide a comprehensive overview of the pathophysiological mechanisms underlying degenerative-dystrophic joint damage and to identify therapeutic approaches to improve joint function and intra-articular cartilage nutrition. This review examines the current etiological factors and pathophysiological mechanisms of degenerative-dystrophic and inflammatory lesions of the large joints of the lower limbs, with a view to explaining the rationale for the use of prolotherapy with hypertonic glucose and/or dextrose solutions. A systematic analysis of studies from 2020 to 2025, drawn from the medical databases PubMed, Google Scholar, Web of Science, and SCOPUS, demonstrates the complexity and cascade of osteoarthrosis pathophysiological mechanisms, which significantly complicate the clinical manifestations of the disease and render drug therapy ineffective. The authors focus on prolotherapy, a regenerative medicine technique that uses hypertonic glucose and/or dextrose solutions, injected into damaged areas of the knee joint, to relieve chronic pain and stimulate the natural regeneration of intraarticular tissues. Clinical data confirms prolotherapy's efficacy in reducing pain and improving joint mobility, often achieving better results than traditional treatments. In their conclusion, the authors emphasize the alternative importance of prolotherapy for patients with gonarthrosis who are looking for non-invasive treatment options.

Methodical development for practical classes in the academic discspline «Current issues of management of patients with cardiac pathology». Higher education level: second (master's). Field of knowledge: 22 "Healthcare". Specialty: 222 "Medicine". Educational and professional program: Medicine

2025-10-20T11:27:40Z

Methodical development for practical classes in the academic discspline «Current issues of management of patients with cardiac pathology». Higher education level: second (master's). Field of knowledge: 22 "Healthcare". Specialty: 222 "Medicine". Educational and professional program: Medicine Savelieva, O. V.; Bondarenko, O. V. Purpose: to explain the essence of the arterial hypertension, the causes of its occurrence, the role of various factors in the etiopathogenesis, approaches to diagnosis, treatment and prevention.

Methodical development for practical classes in the academic discspline «Actual problems of endocrinology». Higher education level: second (master's). Field of knowledge: 22 "Healthcare". Specialty: 222 "Medicine". Educational and professional program: Medicine

2025-10-21T09:21:34Z

Methodical development for practical classes in the academic discspline «Actual problems of endocrinology». Higher education level: second (master's). Field of knowledge: 22 "Healthcare". Specialty: 222 "Medicine". Educational and professional program: Medicine Kravtsova, K. V.; Maistrenko, M. S. The main goals: to indicate the relevance of the topic, know the etiopathogenetic classification of diabetes mellitus, know the risk factors for the development of diabetes mellitus types 1 and 2, know the etiopathogenesis of type 1 and 2 diabetes mellitus, know the diagnostic criteria for diabetes, be able to determine the type of diabetes and the severity and compensation criteria.

Methodical development for induvidual work of hight education applicants in the academic discspline «Current issues of management of patients with cardiac pathology». Higher education level: second (master's). Field of knowledge: 22 "Healthcare". Specialty: 222 "Medicine". Educational and professional program: Medicine

2025-10-21T09:22:16Z

Methodical development for induvidual work of hight education applicants in the academic discspline «Current issues of management of patients with cardiac pathology». Higher education level: second (master's). Field of knowledge: 22 "Healthcare". Specialty: 222 "Medicine". Educational and professional program: Medicine Savelieva, O. V.; Riabinina, A. H. Purpose: to explain the essence of the arterial hypertension, the causes of its occurrence, the role of various factors in the etiopathogenesis, approaches to diagnosis, treatment and prevention.

Methodical development for induvidual work of hight education applicants in the academic discspline «Actual problems of endocrinology». Higher education level: second (master's). Field of knowledge: 22 "Healthcare". Specialty: 222 "Medicine". Educational and professional program: Medicine

2025-10-21T09:23:17Z

Methodical development for induvidual work of hight education applicants in the academic discspline «Actual problems of endocrinology». Higher education level: second (master's). Field of knowledge: 22 "Healthcare". Specialty: 222 "Medicine". Educational and professional program: Medicine Kravtsova, K. V.; Maistrenko, M. S. The main goal: to indicate the relevance of the topic, know the etiopathogenetic classification of diabetes mellitus, know the risk factors for the development of diabetes mellitus types 1 and 2, know thje etiopathogenesis of type 1 and 2 diabetes mellitus, know the diagnostic criteria for diabetes, be able to determine the type of diabetes and the severity and compensation criteria.

Methodical development for practical classes in the academic discspline «Internal medicine». Higher education level: second (master's). Field of knowledge: 22 "Healthcare". Specialty: 222 "Medicine". Educational and professional program: Medicine

2025-10-21T09:24:23Z

Methodical development for practical classes in the academic discspline «Internal medicine». Higher education level: second (master's). Field of knowledge: 22 "Healthcare". Specialty: 222 "Medicine". Educational and professional program: Medicine Zolotarova, N. A.; Potapchuk, O. V.; Savelieva, O. V.; Bondarenko, O. V.; Maistrenko, M. S.; Riabinina, A. H. The main goals: to acquire communication skills and skills of clinical examination and treatment of а patient with arterial hypertension.

Methodical development for practical classes in the academic discspline «Endocrinology». Higher education level: second (master's). Field of knowledge: 22. "Healthcare". Specialty: 222 "Medicine". Educational and professional program: Medicine

2025-10-21T09:25:37Z

Methodical development for practical classes in the academic discspline «Endocrinology». Higher education level: second (master's). Field of knowledge: 22. "Healthcare". Specialty: 222 "Medicine". Educational and professional program: Medicine Potapchuk, O. V.; Alavatska, T. V. The main роаїв: to acquire communication skills and skills of clinical examination and treatment of а patient with arterial hypertension.

Methodical development for induvidual work of hight education applicants in the academic discspline «Internal medicine». Higher education level: second (master's). Field of knowledge: 22 "Healthcare". Specialty: 222 "Medicine". Educational and professional program: Medicine

2025-10-21T09:26:48Z

Methodical development for induvidual work of hight education applicants in the academic discspline «Internal medicine». Higher education level: second (master's). Field of knowledge: 22 "Healthcare". Specialty: 222 "Medicine". Educational and professional program: Medicine Zolotarova, N. A.; Savelieva, O. V.; Bondarenko, O. V.; Maistrenko, M. S.; Riabinina, A. H. The main goals: to acquire communication skills and skills of clinical examination and treatment of a patient with arterial hypertension.