https://repo.odmu.edu.ua:443/xmlui/handle/123456789/19055 2026-04-10T21:01:17Z 2026-04-10T21:01:17Z Rybin, A. I. Kuznetsova, O. V. Zamyshlyak, V. I. https://repo.odmu.edu.ua:443/xmlui/handle/123456789/19397 2026-04-02T07:04:00Z 2026-01-01T00:00:00Z

Molecular characteristics of endometrial cancer: entering the era of precision medicine Rybin, A. I.; Kuznetsova, O. V.; Zamyshlyak, V. I. Endometrial cancer ranks third among cancers affecting women in Ukraine, with a tendency to incidence rate increase every year. The disease is extremely rare in women under 40, and uncommon between 40 and 50, but thereafter, as age increases, the incidence curve rises sharply, peaking at around 63 years of age. As a rule, the disease is diagnosed at an early stage, with an overall 5-year survival rate exceeding 95%. However, this rate drops significantly in cases of regional or distant spread, standing at 68% and 17% respectively. Historically, endometrial carcinoma was classified into two main clinical-pathological types. The first type comprised endometrioid adenocarcinomas, whilst the second included nonendometrioid tumours (serous, clear cell, undifferentiated carcinomas and carcinosarcomas). However, the work carried out in compiling The Cancer Genome Atlas (TCGA) has transformed our understanding of the molecular landscape of endometrial cancer, identifying not two but four molecular subtypes: tumours with mutations in the POLE gene, microsatellite-unstable carcinomas, tumours with mutations in the TP53 gene, and carcinomas of an unspecified molecular subtype. The integration of molecular classification into clinical practice has altered the stratification of patients into risk groups, which, in turn, has influenced the choice of adjuvant therapy. The rehabilitation of patients and ensuring a high quality of life is a very complex task, and to address it, an appropriate balance is required between reducing the risk of recurrence and preventing side effects associated with unjustified escalation of treatment. This review presents information on the molecular subtypes of endometrial cancer, surrogate markers for each molecular subtype, and methods for their determination. The prognostic significance of molecular classification is discussed, as well as the prospects for its use in the design of future studies.

2026-01-01T00:00:00Z Rybin, A. I. Kuznetsova, O. V. https://repo.odmu.edu.ua:443/xmlui/handle/123456789/19169 2026-02-24T07:56:00Z 2025-01-01T00:00:00Z

Modern look on resistance to platinum in patients with the serous ovarian cancer Rybin, A. I.; Kuznetsova, O. V. The study was aimed to determine the platinum-resistance biomarkers in patients with ovarian cancer. 29 platinum-resistant patients with verified serous ovarian cancer of IIIA–IIIC stages were examined, who received 6 courses of adjuvant chemotherapy with platinum preparations (cisplatin 75–100 mg/m2 intravenously with hydration and forced diuresis every 3 weeks) in the postoperative period. As control, 26 patients with non-recurrence of the disease performed for 6 months post-treatment observation (platinum-susceptible tumors) were observed. The expression of ABCA1 is higher in platinum-resistant cases of ovarian cancer. The most pronounced relationship exists between the values of survivin expression, local activity of nitric oxide, the expression of glutathione dependent enzymes, the content of catecholamines in erythrocytes, and the expression of ABCA1 transporter.

2025-01-01T00:00:00Z Rybin, A. Liskovskyi, S. https://repo.odmu.edu.ua:443/xmlui/handle/123456789/18955 2026-01-19T15:36:08Z 2025-01-01T00:00:00Z

When endometrioma becomes malignant: a clinical case and conclusions for oncogynecological practice Rybin, A.; Liskovskyi, S. Objective. To evaluate the clinical and morphological features of malignant transformation of ovarian endometrioma and to emphasise the importance of oncological vigilance in the management of patients with endometriosis.Materials and methods.A clinical case of early endometrioid carcinoma of the ovary against the background of endometrioma in a woman of reproductive age is presented. An analysis of current literature data and ESGO, ESHRE, and JSGO recommendations for the diagnosis and treatment of such patients wasperformed.Results.Morphological and radiological signs of increased oncological risk were identified, which became the basis for timely surgical intervention. Endometrioid carcinoma G1, FIGO IA was histologically verified. Fertility-preserving staging surgery was performed. No recurrence was detected during 24 months of follow-up.Conclusions.Ovarian endometrioma can be a source of early gynaecological cancer processes even in young patients. Vigilance, high-quality imaging and adequate surgical tacticsare key factors for successful treatment.

2025-01-01T00:00:00Z Rybin, A. Liskovskyi, S. https://repo.odmu.edu.ua:443/xmlui/handle/123456789/18933 2026-01-19T15:36:55Z 2025-01-01T00:00:00Z

Epidemiology of papillomavirus infection in Ukraine Rybin, A.; Liskovskyi, S. The aim of this study was to assess the prevalence of HPV infection among women in different regions of Ukraine.Materials and methods. An analysis of data from the Quintip Recordati database, containing 195 records, was performed using frequency analysis methods. The distribution of different HPV strains among the women surveyed, who live in different regions, was determined. An analysis of the frequency of seropositive results depending on the degree of urbanisation was performed. The main ways of preventing HPVinfection were identified.Results. It was found that the number of positive tests accounted for 38.5% of the total sample. When comparing the frequency of detection of high-oncogenic strains, it was found that they are more often registered in cities with larger populations. Conclusions:1. The prevalence of HPV in the women examined is twice the European average.2. The frequency of detection of highly oncogenic HPV strains is higher in urbanised regions.3. Widespread implementation of HPV screening methods in Ukraine could significantly reduce the incidence of cervical cancer.

2025-01-01T00:00:00Z Rybin, A. I. Osyk, V. V. Vastyanov, R. S. Liskovsky, S. V. Artyomenko, V. V. Рибін, А. І. Осик, В. В. Вастьянов, Р. С. Лісковський, С. В. Артьоменко, В. В. https://repo.odmu.edu.ua:443/xmlui/handle/123456789/18678 2026-01-19T15:40:18Z 2025-01-01T00:00:00Z

Quintip Recordati initial data concerning the peculiarities of human papillomavirus infection epidemiology in Ukraine and the prospects for its prevention Rybin, A. I.; Osyk, V. V.; Vastyanov, R. S.; Liskovsky, S. V.; Artyomenko, V. V.; Рибін, А. І.; Осик, В. В.; Вастьянов, Р. С.; Лісковський, С. В.; Артьоменко, В. В. The purpose of the study was to evaluate the human papillomavirus infection prevalence among women in different regions of Ukraine using the Quintip Recordati database. The Quintip Recordati database data, containing 195 records, was analyzed using frequency analysis methods. The distribution features of different HPV strains among the surveyed women living in other regions were determined. The frequency of seropositive results was analyzed also depending on the degree of urbanization. It was found that the number of positive tests was 38.5 % of the total sample size. When comparing the frequency of detection of highly oncogenic strains, it was found that they are more often registered in cities with a larger population. The authors showed that the prevalence of human papillomavirus infection in the surveyed women is twice higher comparing the average European level. Papillomavirus infection high prevalence in Ukraine is supposed to be the result of low vaccination coverage, lack of mass screening, lack of awareness and limited access to preventive programs. The frequency of detection of highly oncogenic HPV strains is higher in urbanized regions. The authors conclude that human papillomavirus infection diagnostic screening methods widespread implementation in Ukraine can significantly reduce the incidence of cervical cancer. They are sure that cervical cancer prevention will continue to rely on secondary prevention methods.; Метою даного дослідження була оцінка поширення папіломавірусної інфекції серед жінок різних регіонів України. Проведений аналіз даних бази Quintip Recordati, що містить 195 записів методами частотного аналізу. Визначені особливості розподілу різних штамів папіломавірусної інфекції серед обстежених жінок, які проживають у різних регіонах. Проведений аналіз частоти серопозитивних результатів в залежності від ступеня урбанізації. Встановлено, що кількість позитивних тестів склала 38.5 % від загальної чисельності вибірки. При порівнянні частоти виявлення високонкогенних штамів встановлено, що вони частіше реєструються у містах з більшим населенням. Автори висвітлили, що поширеність папіломавірусної інфекції в обстежених жінок вдвічі перевищує середньоєвропейські рівні. Скоріше за все, висока поширеність папіломавірусної інфекції в Україні є наслідком низького охоплення вакцинацією, відсутності масового скринінгу, браку обізнаності та обмеженого доступу до профілактичних програм. Частота виявлення високоонкогенних штамів ВПЛ вище в урбанізованих регіонах. Автори висловлюють, що широке впровадження скринінгових методів діагностики ВПЛ в Україні може суттєво зменшити захворюваність на рак шийки матки. Вони впевнені, що профілактика раку шийки матки й надалі спиратиметься на методи вторинної профілактики.

2025-01-01T00:00:00Z Rybin, A. I. Maksymovskyi, V. E. Kuznetsova, O. V. Osyk, V. V. Bohdan, A. S. https://repo.odmu.edu.ua:443/xmlui/handle/123456789/18385 2026-01-19T15:41:27Z 2025-01-01T00:00:00Z

The results of life quality assessment in patients with primary ovarian cancer during treatment: effect of different tactics and HIPEC Rybin, A. I.; Maksymovskyi, V. E.; Kuznetsova, O. V.; Osyk, V. V.; Bohdan, A. S. Ovarian cancer ranks first among gynaecological cancers in terms of mortality, mainly due to late detection and high recurrence rates. The standard treatment for late stages remains cytoreductive surgery combined with systemic chemotherapy. However, survival and quality of life for patients with the traditional approach remain unsatisfactory. Aim: The aim of the study was to analyse the quality of life of patients with primary advanced ovarian cancer depending on the type of treatment tactics before the start of specialized treatment, after cytoreductive surgery in the early and late postoperative periods, during chemotherapy and after the end of specialized treatment.

2025-01-01T00:00:00Z Rybin, A. I. https://repo.odmu.edu.ua:443/xmlui/handle/123456789/18383 2026-01-19T15:43:11Z 2025-01-01T00:00:00Z

The modern look on the platinum-based chemotherapy effectiveness the modern look on the platinum-based chemotherapy effectivenes Rybin, A. I. The aim of the work is to assess the quality of life in platinum-resistant patients with ovarian cancer, depending on the degree of pharmacoresistance and differentiated use of chemotherapy.Materials and methods. The study was conducted on the basis of the University Clinic of the Odessa National Medical University during 2014 -2020 years. 350 patients with adenocarcinoma of the ovaries of III-IV stage were examined, who performed cytoreductive operations.Results and discussion. It is shown that the initial values on the subscales of the questionnaires EORTC QLQ-C30 and FACT-G in patients classified as different clinical groups were compared. When using a differentiated approach in the treatment of patients with OC, the indicators on the scales of physical (PF), role (RF) and emotional functioning (EF) were significantly improved. In addition, the intensity of nausea (NV) and general weakness (FA) decreased in patients of groups III and IV. In the case of differentiated use of chemotherapeutic agents with metabolic support, the total score according to the FACT-G questionnaire was 77.80.9 points in group III, and 77.90.8 points in group IV, which significantly exceeds the received in I and II groups -72.21,2 and 71,60,9 points. The described differences were kept throughout the period of catamnestic observation.Conclusions: The use of a differentiated approach in the treatment of patients with RI significantly improved indicators on the scales of physical (PF), role (RF) and emotional functioning (EF). After treatment, the intensity of nausea (NV) and general weakness (FA) decreased in patients of groups III and IV. The described differences were retained for 12 months after the completion of the course of treatment. Prospects for further research are related to the study of the dynamics of life quality of patients with OC at the subsequent stages of catamnestic observation.

2025-01-01T00:00:00Z Chaika, O. Maksimovskyi, V. Smolyk, D. Ochigava, D. https://repo.odmu.edu.ua:443/xmlui/handle/123456789/18372 2026-01-19T15:46:00Z 2025-01-01T00:00:00Z

A case report of cytoreductive surgery of metastatic adrenal cancer in a patient with tumor progression Chaika, O.; Maksimovskyi, V.; Smolyk, D.; Ochigava, D. Background: Adrenocortical cancer is a rare malignancy with high risk of relapse and disease progression. The approaches to the treatment of relapse cases are not sufficiently clearly defined by current clinical guidelines. Case Description: Male patient O., born in 1967, has been suffering from the cancer of right adrenal gland since 2020. The patient underwent right-sided epinephrectomy in April 2020. Later he got several courses of chemotherapy with the mixed results. Then he underwent laparoscopic cytoreductive assisted excision of the recurrent neoplasm of the right adrenal gland on 04 April 2024, and received everolimus 10 mg per day postoperatively. There was evidence of recurrence of adrenocortical cancer of the adrenal gland with invasion of the fibrous capsule without signs of tumor growth at the edges of the resection. According to immunohistochemistry data, there was a decrease in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression, an increase in Ki-67 expression, and a lack of programmed death- ligand 1 (PD-L1) expression. According to multispiral computed tomography data from May 2024 they found an increase in cells in the lungs by 2 mm, an increase in cells in the liver by 18 and 6 mm, an increase in paracaval lymph nodes by 12 mm. The given case of relapse and progression of the disease is of interest, because the removal of part of the liver during cytoreductive surgery and preservation of the kidney improve the quality of life. Due to limited resources hyperthermic intraperitoneal chemotherapy (HIPEC) and other methods of intraoperative chemotherapy were not applied. Conclusions: Cytoreductive surgery is an important option for complex treatment in the advanced stages of adrenocortical cancer.

2025-01-01T00:00:00Z Rybin, A. I. Kuznetsova, O. V. https://repo.odmu.edu.ua:443/xmlui/handle/123456789/18329 2026-01-19T15:46:58Z 2025-01-01T00:00:00Z

New conception of cancer prevention strategy in the Odesa region: modern program and personificated approach Rybin, A. I.; Kuznetsova, O. V. The authors analyse the state of cancer care in Ukraine and its future trends, taking into account the impact of the war. The paper highlights and analyses the current aspects of the problem of early diagnosis of cancer against the background of reforming medicine in general and the oncological service in particular. The main problems of the oncological service in the region and the state of the organisation of diagnosis of malignant pathology by family doctors are shown. The experience of solving the main problems of the lack of highquality oncological diagnostics, oncological prevention and interaction between primary and other levels of oncological care at the level of Odesa is presented, and a modern approach to improving the state of the oncological service in the region is proposed. The main vectors of development of the oncological service in the framework of healthcare reform in Ukraine are described.; Авторами проведений аналіз стану онкологічного сервісу в Україні та його майбутніх тенденцій з урахуванням та впливом війни. В работі висвітлено та проаналізовано сучасні аспекти проблеми ранньої діагностики онкологічних захворювань на тлі реформування медицини в цілому та онкологічної служби зокрема. Показано основні проблеми онкологічного сервісу регіону та стан організації діагностики злоякісної патології сімейними лікарями. Наведено досвід вирішення на рівні міста Одеса основних проблем відсутності якісної онкодіагностики, онкопревенції та взаємодії між первинною та іншими ланками надання онкологічної допомоги, а також запропонований сучасний підхід до покращення стану онколгічної служби регіону. Описано основні вектори розвитку онкологічної служби в рамках реформування медицини в Україні.

2025-01-01T00:00:00Z Rybin, A. I. https://repo.odmu.edu.ua:443/xmlui/handle/123456789/18321 2026-01-19T15:48:08Z 2025-01-01T00:00:00Z

Biomarkers of platinum resistance in serous ovarian cancer Rybin, A. I. The study was aimed to determine the platinum-resistance biomarkers in patients with ovarian cancer. The expression of ABCA1 is higher in platinum-resistant cases of ovarian cancer. The most pronounced relationship exists between the values of survivin expression, local activity of nitric oxide, the expression of glutathione dependent enzymes, the content of catecholamines in erythrocytes, and the expression of ABCA1 transporter.

2025-01-01T00:00:00Z