Genetic markers of endothelial dysfunction and the structure of dyslipidemia in hypertensive patients with metabolic syndrome

Abstract

The purpose of the research were analysis of the distribution of polymorphisms of eNOS gene and assessment of the features of dyslipidemia depending on the distribution of the isolated and combined polymorphisms of eNOS gene in patients with arterial hypertension (AH) and metabolic syndrome (MS) in Ukrainian population. 128 patients with AH and MS were examined. In the surveyed group polymorphisms T(-786)C and G894T of eNOS gene were determined by PCR. Patients were divided into subgroups with isolated polymorphism T(-786)C, with isolated polymorphism G894T, with combination of two polymorphisms and with "normal genotypes" of eNOS gene. In each subgroup we additionally studied the blood lipid fractions and type of dyslipidemia. The obtained results shows that the features of dyslipidemia in patients with AH and MS is associated with polymorphism of eNOS gene. This association indicates the relationship of endothelial dysfunction with impaired lipid metabolism and shows the possible primacy of endothelial dysfunction. The most unfavorable polymorphism, which is associated with dyslipidemia of very high atherogenic and cardiovascular risks, is a combination of polymorphisms T(-786)C and G894T of eNOS gene.