Короткий опис (реферат):
The aim: To prove safety of the new elixir and determine the effect on regenerative processes under conditions of the experimental trauma.
Materials and methods: The formula of the new dental elixir “Apiprol” includes biologically active components of bee products (propolis, comb capping wax), plant origin compounds. The elixir was single administered, intragastrally to white nonlinear mice weighing (22±2) g at doses at 50 mg/kg, 500 mg/kg, 5000 mg/kg. Acute toxicity of the new hygienic product “Apiprol” was investigated by a single application at the rate of 1000 and 5000 mg/kg animal weight. Subacute (chronic) toxicity was studied when elixir was applied to the skin of 10 mice at a single daily dose of 500 mg/kg for one month. A local irritant effect of the elixir on the oral mucosa was examined in 14 white rats daily after application for 3–5 min. The study of reparative activity was carried out on an experimental model of the wound process. Results: The elixir’s components promote tissues regeneration, rapid epithelialization and wound surfaces healing, having a highly immune stimulating activity and antibacterial properties. Conclusions: The performed study proved a complete safety of the new elixir “Apiprol” and indicated a necessity of the further development of this preparation in order to
create a greater variety of dental means produced in Ukraine.
