Мета дослідження — оцінити функціональний стан антигенпрезентуючих клітин у безплідних пацієнток при зовнішньому генітальному ендометріозі.
The results of observations of 120 infertile patients with external endometriosis are presented in
the article. Age of the examined patients was from 21 to 35 years.
The most frequent among the clinical manifectations of the disease were: chronic pelvic pain in 83
(69.2%) patients, algodismenorrhea in 59 (49.2%), dyspareunia in 46 (38.3%).
Endometriosis of the first and second stage was more frequent — 37 (30.8%) and 41 (34.2%)
cases in diagnostic laparoscopy. Adhesions of different severity were identified in the abdominal cavity
in the majority of the patients (61%). Decreased activity of nature dendritic cells to (5.2±0.5) kl./mm2
СD23 in the functional layer of the endometrium and (6.0±0,5) kl./mm2 СD23 in the basal layer and
increasing of the activity of immature dendritic cells in the basal layer of the endometrium (CD1a 21.2
to 34.2 kl./mm2) were found during immunohistochemical study.
The foregoing demonstrates a functional suppresion of local immunity and may be a factor that
reduces the reproductive function which in turn requires immunomodulation.
