Мета дослідження — порівняти ефективність застосування різних препаратів для
подвійної антитромбоцитарної терапії гострого коронарного синдрому з елевацією
сегмента ST, їх комбінацію з еноксапарином.
In the pathogenesis of acute coronary syndrome (ACS), the leading
role belongs to the activation of platelets. Inhibition of platelet aggregation is of
fundamental importance for the treatment of acute coronary syndrome.
Objective of the study — to compare the effectiveness of various drugs for dual
antiplatelet therapy for acute myocardial infarction with ST-segment elevation, a
combination thereof with enoxaparin.
Materials and methods. The study involved 40 patients admitted to the Odessa
regional clinical hospital with a diagnosis of acute myocardial infarction with STsegment
elevation, which was confirmed by an electrocardiogram, echocardiogram,
laboratory findings. Patients were divided into 2 groups: group 1 (20) as a therapy
received 325 mg of acetylsalicylic acid 180 mg of ticagrelor + enoxaparin 0.5 mg/
kg/bolus on admission to the intensive care unit; Group 2 (20) 325 mg of aspirin +
+clopidogrel 300 mg plus enoxaparin 0.5 mg/kg/bolus. In conducting the study, patients
did not receive other drugs that affect the system of regulation of blood aggregation
state (RBAS). Hemostasis system research was studied with the help of
low-frequency piezoelectric thromboelastography (LFPTEG) immediately after diagnosis,
and on the 5th day of treatment.
