Вплив дисбіозу на стан печінки та ліпідного обміну щурів, які отримували високожировий раціон

Abstract

Метою даної роботи стало дослідження стану печінки та ліпідного обміну щурів, які отримували високожировий раціон в умовах експериментального дисбіозу.

Recently, one of the main reasons for obesity has been regarded the role of the conditionallypathogenic microflora, which produces intestinal endotoxin under the influence of which the lipolysis failure is observed and accumulation of triglycerides (TG) in liver develops (hepatic steatosis). The aim of the work is the study of the influence of the experimental dysbiosis on the state of lipid metabolism in the liver of the rats, being on highly fat diet (HFD). The experiments were conducted on white 18 Wistar line rats, that were divided into 3 equal groups: the 1st one was a norm, the 2nd one received 15 % of sunflower oil (HFD) additionally to the combined feed and the 3rd group got HFD and antibiotic lincomycin dosed at 60 mg/kg with water during 5 days. HFD caused (almost by 31%) increased content of cholesterol in the blood serum. The rats, that received the highly fat diet under the reproducing of disbiosis with antibiotic lincomycin, had increase in the fat mass, the content of TG and cholesterol in the blood serum and in the liver. The received results give the opportunity to suppose, that the hypertriglyceridemia was caused by disbiosis under the influence of LPS. Dysbiosis influences negatively on the state of liver (considerable growth of the level of ALT and alkaline phosphatase in blood serum).