Development of a dosage form based on octenidinium hexafluorosilicate: technological and toxicological aspects: qualification work for obtaining a master's degree in the educational and professional program “Pharmacy, Industrial Pharmacy”

Abstract

The qualification work is devoted to the study of the chronic toxicity of octenidinium hexafluorosilicate and the pharmaceutical justification for the creation of a dental dosage form based on it. The relevance of the work is due to the high prevalence of dental caries, the need to find new effective caries preventive agents, and the prospects for using ammonium hexafluorosilicates as active pharmaceutical ingredients with combined antimicrobial and remineralizing effects.