https://repo.odmu.edu.ua:443/xmlui/handle/123456789/1025 2022-03-20T07:18:03Z https://repo.odmu.edu.ua:443/xmlui/handle/123456789/10154 Synthesis, crystal structure, and spectral characteristics of N-(n-propyl) aminomethanesulfonic acid. Acute toxicity of aminomethanesulfonic acid and its N-alkylated derivatives Khoma, R. E.; Baumer, V. N.; Antonenko, P. B.; Snihach, A. O.; Godovan, V. V.; Ennan, A. A.; Dlubovskii, R. M.; Gelmboldt, V. O.; Хома, Р. Є.; Баумер, В. М.; Антоненко, П. Б.; Снігач, А. О.; Годован, В. В.; Еннан, А. А.; Длубовський, Р. М.; Гельмбольдт, В. О. Aminomethanesulfonic acid (Ia), and its N-methyl (IIa), N-n-propyl (IIIa), N-tert-butyl (IVa) derivatives were synthesized (IIIa has not been previously described) and characterized by means of X-ray diffraction analysis, IR spectroscopy, and mass spectrometry. Aminosulfonic acid 3a of zwitterionic structure crystallizes in the orthorhombic space group Iba2 with the following cell parameters: a=8.8405(6) Å, b=20.6348(12) Å, c=8.0433(7) Å, ===900, V=1467.27(18) Å3. The aqueous solutions of sodium salts (Ib–IVb) were prepared by reacting NaOH with the corresponding Ia–IVa acids in equimolar amounts. The toxicity of Ib–IVb was studied on 132 mice. The derivatives of aminomethanesulfonic acid belong to almost non-toxic compounds (V category of toxicity) following both intraperitoneal and oral administration in mice. According to the LD50 values, the compounds could be ranked in the following order: IIIb (2110 mg/kg)<IIb (2925 mg/kg)<IVb (3020 mg/kg)<Ib (3470 mg/kg). Aminomethanesulfonic acid derivatives may be safely used in buffer solution as well as for further investigation as potential medicine agents.; Синтезовано амінометансульфонову кислоту (Ia) та її N-метил (IIa), N-n-пропіл (IIIa) та N-трет-бутил (IVa) похідні (IIIa раныше не описано), які охарактеризовано за допомогою методів РСА, ІЧ-спектроскопії та мас-спектрометрії. Амінометансульфонати натрію відносяться до практично нетоксичних сполук (V клас токсичності) після внутрішньочеревного та перорального введення у мишей. N-алкіловані похідні аміносульфонованої кислоти можна безпечно використовувати як компоненти буферних розчинів, а також для подальшого дослідження як потенційні лікарські засоби. 2019-01-01T00:00:00Z https://repo.odmu.edu.ua:443/xmlui/handle/123456789/10126 Hexafluorosilicates of bis(carboxypyridinium) and bis(2-carboxyquinolinium) Gelmboldt, V. O.; Koroeva, L. V.; Ganin, E. V.; Fonari, M. S.; Botoshansky, M. M.; Ennan, A. A. The preparation and characterization of three isomeric carboxypyridinium and carboxyquinolinium hexafluorosilicate salts is described. The salts of the general formulas (LH)2[SiF6] (I–III, L = 2-carboxypyridine, 3-carboxypyridine, 4-carboxypyridine) and (LH)2[SiF6]2H2O (IV, L = 2-carboxyquinoline) were prepared from the protonation reaction of the corresponding pyridine carbonic acid by the fluorosilicic acid. The compounds were characterized by IR, mass-spectrometry, thermogravimetric analysis, solubility data, and in the case of III by X-ray crystallography. The relationship between the salts solubility and the H-bonding system was analysed. 2008-01-01T00:00:00Z https://repo.odmu.edu.ua:443/xmlui/handle/123456789/10081 Synthesis, structure and properties of 3-hydroxymethylpyridynium hexafluorosilicate monohydrate as a new potential anticaries agent Gelmboldt, V. O.; Shyshkin, I. O.; Anisimov, V. Yu.; Fonari, M. S.; Kravtsov, V. Ch. The present communication describes of the synthesis, crystal structure, spectral data and properties of 3-hydroxymethylpyridinium hexafluorosilicate monohydrate – a new ammonium hexafluorosilicate, which may find an application as anti-caries agent. Dental caries remains one of the most common chronic diseases with considerable economic and quality-of-life burdens. The search for new effective anticaries agents is therefore an urgent task of modern pharmacy. 2020-01-01T00:00:00Z https://repo.odmu.edu.ua:443/xmlui/handle/123456789/9051 Aminomethanesulfonic Acids as Reaction Products in SO2–NH2Alk–CH2O–H2O Systems: Synthesis and Structure Khoma, R. E.; Gelmboldt, V. O.; Baumer, V. N.; Ennan, A. A.; Vodzinskii, S. V.; Ishkov, Yu. V.; Rakipov, I. M. An original procedure was proposed for the synthesis of a series of aminomethanesulfonic acids AlkNHCH2SO3 (Alk = n-Bu, n-Hept, n-Oct, Bn) and N-tris(hydroxymethyl)methylammonium hydroxymethanesulfonate. The structure of the compounds synthesized was examined by elemental analysis, X-ray diffraction, IR spectroscopy, and mass spectrometry. 2021-01-01T00:00:00Z https://repo.odmu.edu.ua:443/xmlui/handle/123456789/8500 Crystal structures and solubility of 4,4´-bipyridinium and 2-brom-5-methylpyridinium hexafluorosilicates Gelmboldt, V. O.; Koroeva, L. V.; Ganin, E. V.; Fonari, M. S. Hexafluorosilicates with heterocyclic cations are convenient models for the estimation of H-bonds influence on structural characteristics and properties of this onium salts. As a part of our systematic investigation here we describe results of X-ray structure analysis and solubility data determination of the hexafluorosilicates (4,4´-DipyH2)SiF6 (I) and (2-Br-6-CH3C5H3NH)2SiF6·H2O (II). 2012-01-01T00:00:00Z https://repo.odmu.edu.ua:443/xmlui/handle/123456789/8498 Hexafluorosilicates with antibacterial cations Gelmboldt, V.; Anisimov, V.; Prodan, O.; Shishkin, I. The "onium" hexafluorosilicates, in particular, ammonium hexafluorosilicate (NH4)2SiF6 and hexafluorosilicates of amino acids represent in the recent years the objects of intensive research as compounds possessing by the caries-protected and hyposensitive properties. In present communication we describe some results of synthesis and physico-chemical investigations of three new salts with antibacterial cations – (CH)SiF6, (PHMG)(SiF6)1.5 and (CP)2SiF6 (CH – chlorhexidine, PHMG – polyhexamethylene guanidinium, CP – cetylpyridinium). 2014-01-01T00:00:00Z https://repo.odmu.edu.ua:443/xmlui/handle/123456789/8489 Preparation, structure and properties of pyridinium/bipyridinium hexafluorosilicates Gelmboldt, V. O.; Ganin, E. V.; Botoshansky, M. M.; Anisimov, V. Yu.; Prodan, O. V.; Kravtsov, V. Ch.; Fonari, M. S. Pyridinium hexafluorosilicates with the compositions (LH)2[SiF6] (where L = 2,6-bis(hydroxymethyl)-pyridine (I), 4,5-bis(hydroxymethyl)-2-methylpyridine-3-ol (II)), monohydrate (LH)2[SiF6]H2O (L = 2-bromo-6-methylpyridine (III)) and (LH2)[SiF6] (L = 4,40-bipyridine (IV), 2,20-bipyridine (V)) were separated as crystalline products of interaction of fluorosilicic acid with different pyridines. All compounds were characterized by elemental analysis, IR, NMR 19F and mass-spectrometry, solubility data, and X-ray crystallography. The structural study revealed the details of the anion binding and solid state supramolecular architectures provided by the combination of the plethora of intermolecular interactions including strong charge assisted and conventional hydrogen bonds of NH F, OH F types along with O Br contacts and p–p interactions. The relationship between the salts structure and physico-chemical properties is discussed. 2014-01-01T00:00:00Z https://repo.odmu.edu.ua:443/xmlui/handle/123456789/8488 Structure of the 18-crown-6 complex with ammonium hexafluorosilicate and water Fonari, M. S.; Kravtsov, V. Ch.; Simonov, Y. A.; Ganin, E. V.; Gelmboldt, V. O. The crystalline host–guest type complex [(18-crown-6ċNH4)2][SiF6]ċ4H2Ohas been obtained as the result of the interaction of SiF4ċ2NH3 with 18-crown-6 (18C6) in an aqueous medium. Crystal data: monoclinic, space groupC 2 c, a=26.541(2), b=8.363(2), c=20.469(2) Å, β = 122.43(1)°and Z=4. The final R-value is 0.070 for 3253 reflections with I ≥ 2σ(I).The crystals consist of the complex [NH4ċ18C6]+ cations, [SiF6]2-anions and water molecules. The ammonium cation is hydrogen bonded by three of its H-atoms to the crown ether oxygen atoms with N(1) ċO separations2.923(5)–2.940(5) Å and by the fourth H-atom to the fluorine atom of thehexafluorosilicate anion, the N(1)ċF(4) distance being 2.797(6) Å.The conformation of the macrocycle and the hydrogen-bond geometry in thecomplex cation closely resemble those in related adducts between 18-crown-6and ammonium salts. All crystal components are connected via a system of hydrogen bonds into a ribbon alongthe b axis in the unit cell. 2001-01-01T00:00:00Z https://repo.odmu.edu.ua:443/xmlui/handle/123456789/8487 About hydrolytic stability of the chelate complexes [SiF4(2,2′-Bipy)] and [SiF4(1,10-Phen)] Gelmboldt, V. O.; Ganin, Ed. V.; Anisimov, Yu.; Fonari, M. S.; Kravtsov, V. Ch. The products of reaction of fluorosilicic acid (FSA) with organic bases, the fluorosilicates of the relevant "onium" cations, find an application as anti-caries agents, ionic liquids, reagents for modified zeolite catalytic agents, in the synthesis of the complexes of silicon tetrafluoride, fungicides, or in preparation of herbicide-containing mixtures. On the other hand these compounds are of interest for stabilization of various fluorido complexes of silicon, the products of the hydrolytic transformations of FSA. 2014-01-01T00:00:00Z https://repo.odmu.edu.ua:443/xmlui/handle/123456789/8486 “Onium” hexafluorosilicates as new potential caries protective agents Gelmboldt, V. O.; Anisimov, V. Yu.; Fonari, M. S.; Kravtsov, V. Ch. In recent years, the possible usage of ammonium hexafluorosilicate (AHF) as caries-protector and hyposensitive agent in the practice of dentistry was demonstrated. According to silica, as a product of hydrolysis of AHF, acts as a non-trivial catalyst promoting the deposition of calcium phosphate or fluorapatite from saliva; silica is present in sediment that is formed on the dentin surface, thus providing prolonged dentin tubule occlusion. It is supposed that the other "onium" hexafluorosilicates, for example, with bioactive heterocyclic cations must have similar effect. In present communication we describe some results of synthesis, the study of the structure and properties of “onium” hexafluorosilicates – the fluoride containing salts with heterocyclic cations, exhibiting antibacterial, anti-inflammatory and sialagogue activity, as new potential caries protective agents. 2016-01-01T00:00:00Z