https://repo.odmu.edu.ua:443/xmlui/handle/123456789/929 2022-03-20T07:28:29Z 2022-03-20T07:28:29Z Buznyk, O. Pasyechnikova, N. Islam, M. M. Iakymenko, S. https://repo.odmu.edu.ua:443/xmlui/handle/123456789/10893 2022-01-24T09:09:04Z 2015-01-01T00:00:00Z

Bioengineered Corneas Grafted as Alternatives to Human Donor Corneas in Three High-Risk Patients Buznyk, O.; Pasyechnikova, N.; Islam, M. M.; Iakymenko, S. Corneas with severe pathologies have a high risk of rejection when conventionally grafted with human donor tissues. In this early observational study, we grafted bioengineered corneal implants made from recombinant human collagen and synthetic phosphorylcholine polymer into three patients for whom donor cornea transplantation carried a high risk of transplant failure. These patients suffered from corneal ulcers and recurrent erosions preoperatively. The implants provided relief from pain and discomfort, restored corneal integrity by promoting endogenous regeneration of corneal tissues, and improved vision in two of three patients. Such implants could in the future be alternatives to donor corneas for high-risk patients, and therefore, merits further testing in a clinical trial.

2015-01-01T00:00:00Z Veliksar, T. A. Gaidamaka, T. B. Drozhzhina, G. I. Molodaia, A. L. Ivanova, O. N. Dolenko, L. V. Konakh, V. N. https://repo.odmu.edu.ua:443/xmlui/handle/123456789/9380 2021-05-12T06:01:13Z 2020-01-01T00:00:00Z

Comparing the microflora of the conjunctiva and contact lens in therapeutic soft contact lens wearers Veliksar, T. A.; Gaidamaka, T. B.; Drozhzhina, G. I.; Molodaia, A. L.; Ivanova, O. N.; Dolenko, L. V.; Konakh, V. N. Background: More than 125 million (2%) people worldwide wear contact lenses (CL). Rates of CL-associated infections increase with an increase in frequency of wear of CL. Purpose: To compare the bacterial and fungal microflora of the conjunctiva and contact lens in therapeutic soft contact lens (SCL) wearers. Material and Methods: We examined the microflora of the conjunctival surface in 80 therapeutic SCL wearers and of the SCL surface in 235 relevant lenses. Monthly therapeutic SCLs that were discarded after being replaced were sent for bacteriological and mycological culture. We used only the data for the years 2016 through 2019 in the analysis. Results: Pathogenic and/or opportunistic agents were found in samples from 121 SCL (51.5%). Gram positive, Gram negative and fungal species were found in 63.5%, 29.5%, and 7.0%, respectively, of the 121 SCL. Mixed microflora was evident in 14.1% of the 121 SCL. Organisms were isolated from the conjunctiva of 51 (63.8%) of 80 patients. Gram positive, Gram negative and fungal species were found in 75.0%, 20.0%, and 5.0%, respectively, of patients. Mixed microflora was evident in 14.1% of patients. Conclusion: Organisms were isolated from the conjunctiva of 51 (63.8%) of 80 therapeutic SCL wearers and from 121 (51.5%) of 235 SCL (p = 0.06). Conjunctival swabs and SCL swabs harbored pathogenic microorganisms on 26.2% and 26.9% of occasions, respectively. On 32.5% of occasions, there was a difference in species isolated from conjunctival swabs and SCL swabs. This stresses the need for microbiological studies of the conjunctiva and contact lenses in SCL wearers.

2020-01-01T00:00:00Z Ponomarchuk, V. S. Khramenko, N. I. Konovalova, N. V. https://repo.odmu.edu.ua:443/xmlui/handle/123456789/9312 2021-04-28T07:49:55Z 2021-01-01T00:00:00Z

Clinical experience of the use of Vasavital® in dry age-related macular degeneration and ischemic optic neuropathy Ponomarchuk, V. S.; Khramenko, N. I.; Konovalova, N. V. Background: The chronic ischemic process caused by impaired hemodynamics in the eye and brain is a component of the pathogenesis of ischemic optic neuropathy and age-related macular degeneration, and requires prompt and adequate treatment. Purpose: To examine the effect of a one-month course of Vasavital on the function of the visual system and regional hemodynamics in patients with dry age-related macular degeneration and those with ischemic optic neuropathy. Material and Methods: Thirty-two patients with dry age-related macular degeneration (AMD) (mean age, 66 ± 1.5 years) and 22 patients with chronic ischemic optic neuropathy (mean age, 57.0 ± 1.4 years) underwent examination and treatment at the Department of Uveitis and Laboratory for Functional Examination of the Visual System of the Filatov institute. They received a one-month course of Vasavital-only therapy at a dose of one capsule twice a day as an outpatient treatment. Patients reported their complaints and underwent routine eye examination, studies of regional hemodynamics in the eye and brain (by ophthalmic rheography and rheoencephalography with Reocom, the computerized rheography apparatus), and electrophysiological studies of electrically evoked phosphene threshold (EEPT) and critical frequency of phosphene disappearance (CFPD) at two time points: prior to and after a one-month course of Vasavital-only therapy. Results: A one-month course of Vasavital-only therapy resulted in 24% and 9.6%-25% increases in ocular pulse blood filling in patients with chronic ischemic optic neuropathy and patients with age-related macular degeneration with various baseline levels of visual acuity, respectively. In addition, vascular tone in large-and small-caliber ocular vessels decreased significantly, by 12-17%, in patients with chronic ischemic optic neuropathy, and by 10-20%, in patients with age-related macular degeneration, and vascular tone in large-caliber brain vessels (in the vertebral-basilar system) decreased by 21.6% in patients with ischemic optic neuropathy. A course of Vasavital-only therapy resulted in improved optic nerve function in patients with ischemic optic neuropathy, with a 20.5% improvement in electrically evoked phosphene threshold (EEPT), and 22-63% improvement in critical frequency of phosphene disappearance (CFPD); this indicated an improved function of the peripheral as well as central retina.

2021-01-01T00:00:00Z Pasyechnikova, N. V. Naumenko, V. O. Berezovska, K. O. Volkova, Yu. S. Ivanchukova, H. V. Myrnenko, V. V. Anishchenko, Iu. O. https://repo.odmu.edu.ua:443/xmlui/handle/123456789/9311 2021-04-28T07:35:42Z 2020-01-01T00:00:00Z

Concerning the All-Ukrainian research/practice conference «Topical Issues of Ophthalmology»: Report Pasyechnikova, N. V.; Naumenko, V. O.; Berezovska, K. O.; Volkova, Yu. S.; Ivanchukova, H. V.; Myrnenko, V. V.; Anishchenko, Iu. O. The All-Ukrainian research/practice conference "Topical Issues of Ophthalmology" was on September 23- 24, 2020. Organizers of this event were SI «The Filatov Institute of Eye Diseases and Tissue Therapy of NAMS of Ukraine», SO «Ukrainian Society of Ophthalmologists», I. Horbachevsky Ternopil National Medical University with the support of the National Academy of Medical Sciences of Ukraine and the Ministry of Health of Ukraine.

2020-01-01T00:00:00Z Pasyechnikova, N. V. Fedirko, P. A. Babenko, T. F. https://repo.odmu.edu.ua:443/xmlui/handle/123456789/9310 2021-04-28T07:16:46Z 2020-01-01T00:00:00Z

A case of radiation cataract found 29 years after radiation exposure Pasyechnikova, N. V.; Fedirko, P. A.; Babenko, T. F. Background: Radiation cataracts are an acknowledged biological effect of radiation exposure. It has been demonstrated previously that, the mode value for the latent period for the identified post-Chornobyl cases of radiation cataract was 9 years. We present a case of radiation cataract with typical clinical features that manifested 29 years after radiation exposure. Material and Methods: A female patient, born in 1937, worked in the exclusion zone of the Chornobyl Nuclear Power Plant in early May of 1986; she is now under our regular supervision. Because over years, the patient had had the annual routine eye examination (including, but not limited to biomicroscopy, lens examination and red reflex photography using a fundus camera), the time of onset of specific lens opacity could be placed within a period of several months. Results: On examination performed on December 15, 2014, the right lens showed mild peripheral cortical opacity without signs of radiation cataract, and with vacuoli seen in the anterior subcapsular lens region. On examination performed on August 8, 2015, the right eye showed a mild, specific, posterior, central subcapsular opacification. Conclusion: We presented a case of radiation cataract, documented by fundus camera photography, with typical clinical features that manifested 29 years after radiation exposure. Detecting a radiation cataract so late after radiation exposure indicates that the changes in the eye exposed to radiation can be very durable.

2020-01-01T00:00:00Z Muratova, T. M. Venger, L. V. Khramtsov, D. M. Khramtsov, Iu. M. Teliushchenko, V. D. https://repo.odmu.edu.ua:443/xmlui/handle/123456789/9309 2021-04-28T07:00:19Z 2020-01-01T00:00:00Z

Neuro-ophthalmological abnormalities in patients with ischemic stroke in the setting of a stroke center of a university clinic Muratova, T. M.; Venger, L. V.; Khramtsov, D. M.; Khramtsov, Iu. M.; Teliushchenko, V. D. Background: Stroke remains one of the leading causes of death and disability in the world. Most patients with stroke exhibit neuro-ophthalmological abnormalities. Purpose: To assess the frequency of neuro-ophthalmological abnormalities in patients with stroke in the setting of a stroke center of a university clinic. Material and Methods: Two hundred and ninety-eight patients with acute ischemic cerebrovascular accidents who were under observation at the stroke service of the Neurology Department of the Center for Reconstructive and Restorative Medicine (University Clinic) of the Odesa National Medical University from January 2016 through December 2019 were included in the study. Frequency of neuroophthalmological symptoms was assessed at the first neurological examination visit and after ophthalmologist consultation was obtained. Results: Of the 298 patients with stroke, most (162; 54%) were men. Mean patient age was 60.4 ± 1.1 years and mean National Institutes of Health Stroke Scale (NIHSS) score was 10.1 ± 0.9. In addition, of the 298 patients, 163 (54.7%) were admitted to the clinic within a day after onset of clinical symptoms of a stroke. Stroke syndromes were categorized into four subtypes, total anterior circulation infarcts (TACI), partial anterior circulation infarcts (PACI), lacunar circulation infarcts (LACI), and posterior circulation infarcts (POCI). PACI were the most common (139 cases or 36.6%), followed by LACI (88 cases or 29.5%), whereas TACI were least common (28 cases or 10.5%). Of special interest were POSI (43 cases or 14.4%). Fourteen patients with POSI (4.7% of the total study patients) had lesions of the midbrain and pons. Neuro-ophthalmological manifestations were found in 88.8% of patients. Of these manifestations, anisocoria was the most common (60.1%), followed by hemianopia (27.9%), diplopia (22.1%) and visuospatial neglect (19.5%), and various oculomotor abnormalities. Internuclear ophthalmoplegia (INO) was found only in 8 cases (2.7%). Conclusion: Diagnosing neuro-ophthalmological syndromes requires coordinated efforts of the neurologist and ophthalmologist in the setting of a multi-professional team.

2020-01-01T00:00:00Z Yakymenko, I. V. Ulianova, N. A. Venger, L. V. Shakun, K. S. https://repo.odmu.edu.ua:443/xmlui/handle/123456789/9308 2021-04-28T06:05:48Z 2019-01-01T00:00:00Z

Results of using the novel method for predicting the development and course of glaucomatous optic neuropathy in POAG Yakymenko, I. V.; Ulianova, N. A.; Venger, L. V.; Shakun, K. S. Background: Given that the rates of glaucoma-induced visual incapacitation are steadily increasing, predicting glaucomatous optic neuropathy is important. Purpose: To determine the diagnostic importance of the method proposed for the predicting the development and course of glaucomatous optic neuropathy in primary open-angle glaucoma (POAG) based on SweptSource-OCT-derived morphometric characteristics of the lamina cribrosa and daily intraocular pressure (IOP) in the clinical practice. Materials and Methods: Thirty patients were under observation. At baseline, the risk for the development of glaucomatous optic neuropathy in glaucoma suspects or the risk for disease progression in patients with already diagnosed POAG was assessed using our method. The latter is based on the determination of pressure exerted on the ganglion axons at the level of lamina cribrosa, given the specified IOP value and individual morphometric characteristics of the lamina cribrosa. Patients were divided into three groups depending on their risk levels. A DRI OCT Triton plus swept source OCT system (Topcon, Tokyo, Japan) was used to assess morphometric characteristics of the retina (ganglion cell complex thickness) and optic disc (lamina cribrosa thickness and diameter). The further course of the glaucomatous progression was studied using macular GCL++ characteristics. Results: At month 18, GCC thickness loss was statistically significantly larger in the moderate-risk group than in the low-risk group (p=0.001). In addition, it was statistically significantly larger in the high-risk group than in the low-risk group (p=0.00001) and in the moderate-risk group (p=0.00013). In the low-risk group, mean GCC thickness was 92.90±3.28 μm at baseline and 91.95±3.24 μm at month 18; however, the GCC thickness loss was not statistically significant (p=0.838). Conclusion: First, our method for predicting the development and progression of glaucomatous optic neuropathy in POAG based on SS-OCT-derived morphometric characteristics of the lamina cribrosa and daily IOP level enables determining the risk level of glaucomatous progression, which has been evidenced by the results of a prolonged observation. Second, significant macular GCC thinning was noted in 50% of cases of the high-risk group, even with a normal IOP level. Finally, introduction of the proposed method into clinical practice would enable planning effective glaucoma management aimed at prevention of optic nerve atrophy.

2019-01-01T00:00:00Z Boichuk, I. Naumenko, V. Zborovska, O. Dorokhova, O. https://repo.odmu.edu.ua:443/xmlui/handle/123456789/9038 2021-03-22T08:38:07Z 2019-01-01T00:00:00Z

Characteristics of eye movements in the anti-terrorist operation area’s residents with potential posttraumatic stress disorder Boichuk, I.; Naumenko, V.; Zborovska, O.; Dorokhova, O. Purpose of the present paper was to study the characteristics of eye movements in individuals residing in the anti-terrorist operation area and to compare those with eye movements in healthy individuals. Material and Methods. The study involved patients undergoing outpatient examination: Study group, 120 individuals residing in the ATO zone; Control group, 80 individuals residing in Odessa and Odessa Region. The patients were selected for additional examination at presentation by doctors in outpatient department if the patient’s behavior was a matter of concern for a doctor. The patients were examined accommodation, convergence, conjugate eye movements in 9 eye positions, and horizontal and vertical saccades. Results. The individuals residing in the ATO zone had conjugate eye movement disorders (44.8%), decreased mean values of accommodation (39.8%) and convergence (45%), and impaired visual acuity. Among saccade disorders, hypermetric saccades were most frequently recorded: 25% vs.6.2% in Study and Control groups, respectively, р = 0.0035. Conclusion. The individuals, residing in the ATO area had impaired visual function (visual acuity, convergence, and accommodation) comparing to those residing in Odessa and Odessa region. Significant disorders revealed in vergence and conjugate eye movements, accommodation, and saccades in Study group can be used as objective signs of PTSD.

2019-01-01T00:00:00Z Danyk, Y. Zborovska, O. Pasyechnikova, N. https://repo.odmu.edu.ua:443/xmlui/handle/123456789/9036 2021-03-22T07:52:20Z 2020-01-01T00:00:00Z

Strategies for the development of cyber-ophthalmology Danyk, Y.; Zborovska, O.; Pasyechnikova, N. Background: Making the tertiary management of eye diseases improved and widely available for all social groups in all parts of Ukraine is a pressing challenge for not only the Ministry of Health, but also for the state. Purpose: To provide scientific and theoretical assessment of establishing a new branch of ophthalmology, cyber-ophthalmology. Results: We demonstrated that the studied issue is relevant and important in the light of developments in tele- and cyber-medicine, expansion of application of information technologies to and introduction of artificial intelligence in medicine and in particular in ophthalmology. Conclusion: Cyber-ophthalmology is becoming reality and a systematically important branch of ophthalmology. Research in and developments of this branch are essential for providing tertiary eye disease management and improved disease treatment efficacy for all social groups.

2020-01-01T00:00:00Z Dorokhova, O. Zborovska, O. Guanjun, Men https://repo.odmu.edu.ua:443/xmlui/handle/123456789/9035 2021-03-22T07:39:40Z 2020-01-01T00:00:00Z

Relationship of the ocular surface temperature with the clinical features of induced non-infectious anterior and intermediate uveitis in rabbits Dorokhova, O.; Zborovska, O.; Guanjun, Men Background: It is an important challenge to develop objective methods for assessing intraocular inflammation. Purpose: To assess the relationship of the ocular surface temperature in the projection of the ciliary body with the clinical signs of induced non-infectious anterior and intermediate uveitis in rabbits. Material and Methods: Measurements of the ocular surface temperature in the projection of the ciliary body were performed in 17 Chinchilla rabbits with induced non-infectious anterior and intermediate uveitis. Results: The clinical signs of uveitis which characterize inflammatory activity were most pronounced on day 1 of induced non-infectious anterior and intermediate uveitis in rabbits, gradually decreased thereafter and were not observed by day 19. There was a weak correlation between the ocular surface temperature in the projection of the ciliary body and weighted score of the clinical signs of anterior and intermediate uveitis (r = 0.32; р = 0.0001) for all follow-up time points. The difference in temperature between the affected eye and the intact eye correlated with the weighted score of clinical signs of experimental uveitis activity. Thus, this correlation was strong (r = 0.73; р = 0.008) on day 1, became weaker on subsequent days, and became not significant from day 8 (r = 0.4; р = 0.19). The difference in the ocular surface temperature in the projection of the ciliary body between the affected eye and the fellow eye does not clearly represent an ocular temperature response to the induced disease due to the presence of the autonomic nervous system (ANS) response in the form of an increase in the temperature of the fellow eye. Therefore, the presence of this ANS response should be taken into account in calculations, and the comparison should be conducted against reference temperature values of intact eyes, but not against the fellow eye.

2020-01-01T00:00:00Z